急性自发性脑出血血清NGAL、TNC表达及其与预后关系  

The expression of serum NGAL and TNC in acute spontaneous cerebral hemorrhage and its relationship with prognosis

作　　者：韩海会 Han Haihui(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471000)

机构地区：[1]河南科技大学第一附属医院,河南洛阳471000

出　　处：《辽宁医学杂志》2022年第4期35-37,共3页Medical Journal of Liaoning

摘　　要：目的 探讨急性自发性脑出血血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、肌糖蛋白-C(TNC)表达及其与预后关系。方法 采用回顾性分析方法,选择2018年2月至2020年2月河南科技大学第一附属医院收治的102例急性自发性脑出血患者为研究组,选择同期在我院体检86例健康者为对照组,对比研究组治疗前与对照组体检时血清NGAL、TNC水平。统计研究组预后情况,采用病情伤残量表(mRS)评估患者的预后情况,将患者分为预后不良(mRS>3分)和预后良好(mRS≤3分)。比较预后良好者和预后不良者治疗前血清NGAL、TNC水平,分析研究组治疗前血清NGAL、TNC水平对急性自发性脑出血患者预后的预测价值。结果 研究组血清NGAL、TNC水平均高于对照组(P<0.05)。102例急性自发性脑出血,预后良好者62例,占比为60.78%,预后不良者40例。预后不良者血清NGAL、TNC水平均高于预后良好者(P<0.05)。接受者操作特征曲线(ROC)曲线结果显示,血清NGAL、TNC水平及二者联合评估急性自发性脑出血患者预后的曲线下面积(AUC)和最佳截断值分为[AUC=0.806,95%CI(0.718~0.895),最佳截断值为395.12ng/mL]、[AUC=0.762,95%CI(0.668~0.857),最佳截断值为70.24ng/mL]、[AUC=0.915,95%CI(0.851~0.980)],约登指数分别为0.562、0.486、0.612(P<0.05)。结论 急性自发性脑出血血清NGAL、TNC水平高于正常人群,血清NGAL、TNC水平二者联合评估急性自发性脑出血患者的预后具有较高价值。Objective To investigate the expression of serum neutrophil gelatinase-associated lipocalin(NGAL)and myosin-C(TNC)and their relationship with prognosis in acute spontaneous cerebral hemorrhage.Methods A retrospective analysis method was used to select 102 patients with acute spontaneous cerebral hemorrhage admitted to the First Affiliated Hospital of Henan University of Science and Technology from February 2018 to February 2020 as the research group,and 86 healthy patients who received physical examination in our hospital during the same period were selected as controls Group,compared the serum NGAL and TNC levels of the study group before treatment and the control group,the prognosis of the study group was calculated,used the Disability Scale(mRS)to assess the prognosis of patients,they were divided into poor prognosis(mRS>3 points)and good prognosis(mRS≤3 points).The serum NGAL and TNC levels before treatment were compared between those with good prognosis and those with poor prognosis,and the predictive value of serum NGAL and TNC levels before treatment in the study group on the prognosis of patients with acute spontaneous cerebral hemorrhage was analyzed.Results The serum NGAL and TNC levels in the study group were higher than those in the control group(P<0.05).In 102 cases of acute spontaneous cerebral hemorrhage,62 cases had a good prognosis,accounting for 60.78%,and 40 cases had a poor prognosis.The serum NGAL and TNC levels of patients with poor prognosis were higher than those with good prognosis(P<0.05).The results of the receiver operating characteristic curve(ROC)curve showed that the serum NGAL and TNC levels and the area under the curve(AUC)and the best cut-off value for the combined evaluation of the prognosis of patients with acute spontaneous cerebral hemorrhage were divided into[AUC=0.806,95%CI(0.718~0.895),the best cut-off value was 395.12 ng/mL],[AUC=0.762,95%CI(0.668~0.857),the best cut-off value was 70.24 ng/mL],[AUC=0.915,95%CI(0.851~0.980)],Youden index were 0.562,0.486,0.612 respective

关 键 词：急性自发性脑出血 中性粒细胞明胶酶相关脂质运载蛋白 肌糖蛋白-C 预后 

分 类 号：R743.34[医药卫生—神经病学与精神病学]