成纤维细胞生长因子-23在慢性肾脏病血管钙化中的作用  

Role of fibroblast growth factor-23 in vascular calcification of chronic kidney disease

作　　者：董佳慧 焦军东[1] DONG Jia-hui;JIAO Jun-dong(Department of Nephrology,Second Affiliated Hospital of Harbin Medical University,Harbin,Helongjiang,150081,China)

机构地区：[1]哈尔滨医科大学附属第二医院肾内科,黑龙江哈尔滨150086

出　　处：《心血管康复医学杂志》2022年第4期513-516,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：血管钙化(VC)是血液透析患者发病率和死亡率高的重要原因。慢性肾脏病(CKD)患者VC加重与矿物质代谢异常、内源性钙化抑制因子和慢性炎症等多种方面相互关联的机制有关。近年来,成纤维细胞生长因子-23(FGF-23)与VC的相关性受到越来越多的关注。本文就FGF-23在CKD患者VC方面研究的进展作一综述。Vascular calcification(VC)is an important cause of high morbidity and mortality in hemodialysis patients.Aggravation of VC in patients with chronic kidney disease(CKD)is related to a variety aspect of interrelated mechanisms,such as abnormal mineral metabolism,endogenous calcification inhibitors and chronic inflammation etc.In recent years,the correlation between fibroblast growth factor-23(FGF-23)and VC has attracted more and more attention.The present article makes a review on research progress of FGF-23 in VC aspect of CKD patients.

关 键 词：肾疾病 血管钙化 成纤维细胞生长因子23 

分 类 号：R692[医药卫生—泌尿科学]