假体周围感染患者免疫微环境特点与相关治疗策略  

Characteristics of the immune microenvironment and related treatment strategies in patients with periprosthetic joint infection

作　　者：祖力皮喀尔·买买提 徐驰[1] 付君[1] 李倬 郝立波[1] 柴伟[1] 陈继营[3] Maimaiti Zulipikaer;Xu Chi;Fu Jun;Li Zhuo;Hao Libo;Chai Wei;Chen Jiying(Department of Orthopaedics,the Fourth Medical Centre,Chinese People′s Liberation Army General Hospital,Beijing 100048,China;Medical School of Nankai University,Tianjin 300074,China;Department of Orthopaedics,the First Medical Centre,Chinese People′s Liberation Army General Hospital,Beijing 100039,China)

机构地区：[1]解放军总医院第四医学中心骨科医学部,北京100048 [2]南开大学医学院,天津300074 [3]解放军总医院第一医学中心骨科,北京100039

出　　处：《中华外科杂志》2022年第8期796-800,共5页Chinese Journal of Surgery

基　　金：国家自然科学基金(82002323)。

摘　　要：假体周围感染(PJI)的疾病进展涉及病原体、生物材料和宿主之间的复杂的免疫调控, 与免疫细胞的比例以及免疫检查点分子浓度的改变均有相关性。假体、生物膜、微生物与宿主构成特殊而复杂的免疫微环境, 充分研究植入物相关感染中免疫微环境特点以及免疫治疗的潜在靶点, 有望为治疗PJI提供全新的临床治疗方向。本文通过分析近年来国内外PJI与免疫调控的相关文献, 总结免疫微环境特点与相关免疫治疗的潜在价值, 希望为靶向治疗PJI提供新思路。Periprosthetic joint infection(PJI)involves complex immunomodulatory interactions between pathogens,biomaterials,and hosts,and correlates with alterations in the ratio of immune cells as well as in the concentration of immune checkpoint molecules.Prosthesis,biofilm,microorganisms,and host constitute a special and complex immune microenvironment.Fully studying the characteristics of immune microenvironment and potential targets of immunotherapy in orthopedic implant-associated infections are expected to provide a new direction for clinical treatment of PJI.An overview of the literature related to PJI and immune regulation at domestic and international sites was conducted to summarize and analyze the characteristics of the immune microenvironment and the potential value of related immunotherapy,aiming to provide new insights for the targeted treatment of PJI.

关 键 词：关节成形术 置换 假体相关感染 免疫微环境 髓源性免疫抑制细胞 免疫调节 治疗策略 

分 类 号：R687.4[医药卫生—骨科学]