Polymerization-Amplified Photoacoustic Signal by Enhancing Near-Infrared Light-Harvesting Capacity and Thermal-to-Acoustic Conversion  

作　　者：He-Qi Gao Jing-Tian Zhang Xin-Wen Qi Di Jiao Yu-Ning Hong Ke Shan Xiang-Long Kong Dan Ding 

机构地区：[1]Key Laboratory of Bioactive Materials,Ministry of Education,and College of Life Sciences,Nankai University,Tianjin 300071,China [2]Center for AIE Research,Shenzhen Key Laboratory of Polymer Science and Technology,Guangdong Research Center for Interfacial Engineering of Functional Materials,College of Materials Science and Engineering,College of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen 518060,China [3]Department of Chemistry and Physics,La Trobe Institute for Molecular Science,La Trobe University,Melbourne,Victoria,3086,Australia [4]Shandong Artificial intelligence Institute and Shandong Computer Science Center,Qilu University of Technology,Jinan 250353,China

出　　处：《Chinese Journal of Polymer Science》2022年第9期1090-1100,共11页高分子科学（英文版）

基　　金：supported by the National Key R&D Program of China (Intergovernmental Cooperation Project, 2017YFE0132200);the National Natural Science of Fundation of China (Nos.51961160730, 51873092, and 81921004);the Fundamental Research Funds for the Central Universities;the Tianjin Science Fund for Distinguished Young Scholars (19JCJQJC61200)

摘　　要：As a frontier imaging technique for biomedical applications,photoacoustic(PA)imaging has been developed rapidly.The development of new design strategies and excellent PA imaging reagents to boost PA conversion is eagerly desirable for high quality PA imaging but complicated to realize.Herein,we develop a new strategy in which PA imaging reagents with better properties can be easily optimized by polymerization.A series of new PA imaging reagents were designed and synthesized.The polymerization strategy can effectively promote the PA signal by specifically increasing the thermal-to-acoustic conversion efficiency.As these materials shared the same building units,the optimized effectiveness of polymerization strategy in terms of near-infrared light-harvesting capacity and thermal-to-acoustic conversion efficiency are discussed,rationally.The polymers with intense intramolecular motion exhibit an amplified PA signal by elevating thermal-to-acoustic conversion and its higher light-harvesting capability at redshifted region.The simultaneously strong PA signal and photothermal conversion efficiency of p-TTmB NPs enable precise PA imaging and effective photothermal therapy.This work highlights a simple and available design guideline of polymerization for amplifying the PA effect and optimizing existing materials.

关 键 词：Intramolecular motion Thermal-to-acoustic conversion Photoacoustic imaging Photothermal conversion efficiency POLYMERIZATION 

分 类 号：R318[医药卫生—生物医学工程]