呼吸道微生态与支气管肺发育不良研究进展  

Research progress of respiratory microecology and bronchopulmonary dysplasia

作　　者：郑倩 应俊杰 石晶 母得志 Zheng Qian;Ying Junjie;Shi Jing;Mu Dezhi(Department of Pediatrics,West China Second Hospital,Sichuan University Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,Chengdu 610041,China)

机构地区：[1]四川大学华西第二医院儿科,出生缺陷与相关妇儿疾病教育部重点实验室,成都610041

出　　处：《中华实用儿科临床杂志》2022年第15期1197-1200,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金(81630038, 81971433);国家重点研究发展计划(2017YFA0104204);四川省重点研发项目(2020YFS0041)。

摘　　要：支气管肺发育不良(BPD)是早产儿常见的呼吸系统疾病,感染、炎症反应、氧化应激等是BPD主要的致病机制。研究发现,肺部微生物定植可能从围生期就开始,并受多种因素的影响而动态变化。呼吸道微生态失调可能通过触发氧化应激反应、抑制miR-876-3p表达、改变肺部代谢及减弱局部屏障功能等机制参与BPD的发生与进展;同时,肺发育异常及肺损伤也会对呼吸道微生态产生影响,这种影响甚至会持续到成年后。益生菌具有抗炎、抗感染及抗氧化等作用,补充益生菌制剂可能通过调节呼吸道微生态,促进肺发育、改善肺损伤。现对新生儿呼吸道微生态的建立及动态变化进行阐述,并探讨呼吸道微生态在BPD发病机制及防治中的作用。Bronchopulmonary dysplasia(BPD)is a common respiratory disease in preterm infants.Infection,inflammation and oxidative stress are the main pathogenic mechanisms of BPD.Recent studies have shown that the colonization of pulmonary microorganisms begins from the perinatal period and dynamically changed by multiple factors.Respiratory microecology dysbiosis may trigger oxidative stress,inhibit the expression of miR-876-3p,change pulmonary metabolism and weaken local barrier function,thereby leading to the occurrence and progress of BPD.At the same time,abnormal pulmonary development and lung injury also exert impact on respiratory microecology,and the impact even lasts till adulthood.Probiotics have anti-inflammatory,anti-infection and antioxidant effects.Supplementation of probiotics may promote lung development and alleviate lung injury conditions by regulating respiratory microecology.In this article,the establishment and dynamic changes of neonatal respiratory microecology were elaborated,and the role of respiratory microecology in the pathogenesis,prevention and treatment of BPD was explored.

关 键 词：呼吸道微生态 肺发育 支气管肺发育不良 益生菌 

分 类 号：R722.6[医药卫生—儿科]