Predictors of anti-SARS-CoV-2 seropositivity:An Egyptian population-based study  

作　　者：Engy Mohamed El-Ghitany Ayat Ashour Azza Galal Farghaly Mona H.Hashish Eman A.Omran 

机构地区：[1]Department of Tropical Health,High Institute of Public Health,Alexandria University,Alexandria,Egypt [2]Department of Family Health,High Institute of Public Health,Alexandria University,Alexandria,Egypt [3]Department of Microbiology,High Institute of Public Health,Alexandria University,Alexandria,Egypt

出　　处：《Infectious Medicine》2022年第2期113-123,共11页感染医学（英文）

基　　金：supported financially by the Science and Technology Development Fund(STDF),Egypt;Project No.43834.

摘　　要：Background:Population-based studies on the determinants of COVID-19 seroprevalence constitute a cornerstone in guiding appropriate preventive measures.Such studies are scarce in Egypt,thus we conducted this study to explore risk factors for SARS-CoV-2 seropositivity.Methods:This survey included 2919 participants from 10 Egyptian governorates.Sera were tested for SARS-CoV-2 spike(S)and nucleocapsid(N)antibodies.Univariate and multivariate analyses were performed to identify associated factors and predictors of seropositivity regarding sociodemographic factors,clinical data,and personal practices of participants.A subgroup analysis was performed to investigate the occupational risks of seropositivity.Results:Seropositivity was recorded in 1564 participants(53.6%).Independent predictors of seropositivity in-cluded non-smokers(aOR=1.817;95%CI:1.407-2.346,p=0.000),having blood group A(aOR=1.231;95%CI:1.016-1.493,p=0.034),a history of COVID-19 infection(aOR=2.997;95%CI:2.176-4.127,p=0.000),COVID-19 vaccination(aOR=4.349;95%CI:2.798-6.759,p=0.000),higher crowding index(aOR=1.229;95%CI:1.041-1.451,p=0.015),anosmia and/or ageusia(aOR=3.453;95%CI:2.661-4.481,p=0.000)and history of fever(aOR=1.269;95%CI:1.033-1.560,p=0.023).Healthcare worker and Obesity/overweight were additional significant predictors of seropositivity among the working participants(aOR=1.760;95%CI:1.301-2.381,p=0.000 and aOR=1.384;95%CI:1.059-1.808,p=0.019,respectively).Additional factors showing association with seropositivity in the univariate analysis were:female gender,age group(15-39 years),higher educational level(preparatory and above),lack of environmental disinfection and having roommates at the workplace.There was a positive correlation between the titers of both antibodies.Age was weakly corre-lated with anti-S titer,while anti-N was significantly correlated with the number of protective measures applied by the participants.Both antibodies were significantly correlated with adult BMI,while both were significantly negatively correlated with the

关 键 词：COVID-19 PREDICTORS SEROPREVALENCE Anti-spike Anti-nucleocapsid 

分 类 号：R373[医药卫生—病原生物学]