绝经后女性血清Ⅰ型胶原交联羧基端肽相关因素的研究  

Factors associated with serum carboxy-terminal cross-linked telopeptide of type Ⅰ collagen in postmenopausal women

作　　者：王冠 滕俊强 章羽婷 边平达[2] 应奇峰[3] 陈锦平[3] WANG Guan;TENG Junqiang;ZHANG Yuting(Department of Rehabilitation Medicine,Center for Rehabilitation Medicine,Rehabilitation&Sports Medicine Research Institute of Zhejiang Province,Zhejiang Provincial People's Hospital/People’s Hospital of Hangzhou Medical College,Hangzhou 310014,China)

机构地区：[1]浙江省人民医院/杭州医学院附属人民医院康复中心,浙江省康复与运动医学研究所康复医学科,浙江杭州310014 [2]浙江省人民医院/杭州医学院附属人民医院康复中心,浙江省康复与运动医学研究所老年医学中心,浙江杭州310014 [3]浙江省人民医院/杭州医学院附属人民医院康复中心,浙江省康复与运动医学研究所骨质疏松诊疗中心,浙江杭州310014 [4]浙江中医药大学研究生院

出　　处：《全科医学临床与教育》2022年第8期683-684,688,共3页Clinical Education of General Practice

基　　金：浙江省医药卫生平台重点资助计划项目(2016ZDA002)。

摘　　要：目的 寻找绝经后女性血清Ⅰ型胶原交联羧基端肽(CTX)的相关因素。方法 对225例绝经后女性进行伴随疾病和生活方式的调查,并进行骨代谢标志物和血生化检测,运用多元回归分析方法筛选绝经后女性血清CTX的独立相关因素。结果 慢性胃炎、喝牛奶和甲状旁腺素是绝经后女性血清CTX的相关因素(t分别=2.83、-2.76、4.46,P均<0.05)。结论 坚持喝牛奶、防治慢性胃炎、降低甲状旁腺素水平,可能有助于降低绝经后女性血清CTX水平。Objective To probe into factors associated with serum carboxy-terminal cross-linked telopeptide of type Ⅰcollagen(CTX)in postmenopausal women. Methods A survey on underlying chronic diseases and lifestyle factors were performed in 225 postmenopausal women.The serum levels of bone metabolism markers and biomedical index were detected.Multivariate regression analysis were performed to discover independent factors associated with serum CTX. Results Chronic gastritis,drinking milk and parathyroid hormone were independent factors associated with serum CTX in postmenopausal women(t=2.83,-2.76,4.46,P<0.05). Conclusion Insisting on dringing milk,preventing and curing chronic gastritis,and reducing parathyroid hormone level may help to decrease the level of serum CTX in postmenopausal women.

关 键 词：Ⅰ型胶原交联羧基端肽 甲状旁腺素 慢性胃炎 绝经后女性 

分 类 号：R580[医药卫生—内分泌]