ROS-responsive thioether-containing hyperbranchede polymer micelles for light-triggered drug releas  

作　　者：Guanchun Wang Ping Huang Lei Wang Xinliang Chen Yongfeng Zhou Wei Huang Deyue Yan 

机构地区：[1]School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai,China [2]The International Peace Maternity and Child Health Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China

出　　处：《SmartMat》2022年第3期522-531,共10页智能材料（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Number:21702097;Postdoctoral Science Foundation of China,Grant/Award Number:2020M671096;Medical Engineering Cross Project of Shanghai Jiao Tong University,Grant/Award Number:YG2019ZDA05;National Key Research and Development Plan of China,Grant/Award Number:2016YFA0201500。

摘　　要：As a kind of promising drug carriers,smart polymers have attracted much attention due to the effective and controlled drug release in target cells.Herein,a reactive oxygen species(ROS)-responsive thioether-containing amphiphilic hyperbranched polymer prepared from MTPA and TMPTGE(HBPMT)is synthesized from 3-(methylthio)propylamine(MTPA)and trimethylolpropane triglycidyl ether(TMPTGE)by the amine-epoxy click reaction via A2+B3 onepot approach.Benefiting from its inherent amphiphilic nature,HBPMT can selfassemble into stable micelles in water.Triggered by H_(2)O_(2),these micelles can be dissociated rapidly because hydrophobic thioether segments in their cores are oxidized into hydrophilic sulfoxide or sulfone groups.Additionally,the ROS produced by photosensitizer under light irradiation can also play the same role of H_(2)O_(2).Such HBPMT micelles can be utilized to encapsulate anticancer drug paclitaxel(PTX)and photosensitizer chlorin e6(Ce6)simultaneously for drug delivery and control release.The methyl thiazolyl tetrazolium assay toward MCF-7 tumor cells(a human breast adenocarcinoma cell line)indicates that these micelles encapsulated with PTX and Ce6 exhibit a significant combinational efficacy of cell proliferation inhibition,which means the promising potential for synergistic chemo-photodynamic cancer therapy.Such a novel nanocarrier based on amphiphilic to hydrophilic transition would provide a candidate for controlled drug release and cancer combination therapy.

关 键 词：drug delivery hyperbranched polymer PHOTOSENSITIZER ROS-responsiveness triggered drug release 

分 类 号：O62[理学—有机化学]