匹多莫德联合屋尘螨变应原制剂治疗小儿变应性鼻炎合并哮喘的临床疗效  

Clinical effects of pidotimod combined with house dust mite allergen preparation in the treatment of children with allergic rhinitis complicated with asthma

作　　者：邓春燕[1] 刘贺临[2] DENG Chunyan;LIU Helin(Department of Pediatrics,Xiaogan Central Hospital,Xiaogan,Hubei,432000,China;Pediatric Intensive Care Unit,Xiaogan Central Hospital,Xiaogan,Hubei,432000,China)

机构地区：[1]孝感市中心医院儿科,湖北孝感432000 [2]孝感市中心医院儿童重症监护室,湖北孝感432000

出　　处：《当代医学》2022年第22期66-68,共3页Contemporary Medicine

摘　　要：目的探讨匹多莫德联合屋尘螨变应原制剂治疗小儿变应性鼻炎合并哮喘的临床疗效。方法选取2018年6月至2019年6月本院收治的68例变应性鼻炎合并哮喘患儿作为研究对象,采用随机数字表法分为对照组和观察组,各34例。对照组采用屋尘螨变应原制剂治疗,观察组采用匹多莫德联合屋尘螨变应原制剂治疗,比较两组治疗前后各项免疫指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、肺功能指标及临床疗效。结果治疗前,两组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比较差异无统计学意义;治疗后,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)等均高于对照组,CD8^(+)低于对照组,差异有统计学意义(P<0.05)。治疗前,两组FVC、MVV比较差异无统计学意义;治疗后,观察组FVC、MVV均高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为94.12%,明显高于对照组的73.53%,差异有统计学意义(P<0.05)。结论匹多莫德联合屋尘螨变应原制剂治疗小儿变应性鼻炎合并哮喘临床疗效显著,可提高患者免疫力,增强肺功能,值得临床推广应用。Objective To investigate the clinical efficacy of pidotimod combined with house dust mite allergen preparation in the treatment of children with allergic rhinitis complicated with asthma.Methods 68 children with allergic rhinitis complicated with asthma who were treated in our hospital from June 2018 to June 2019 were selected as the research subjects,and they were divided into the control group and the observation group by random number table method,with 34 cases in each group.The control group was treated with house dust mite allergen preparation,and the obser-vation group was treated with pidotimod combined with house dust mite allergen preparation.The immune indexes(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),pulmonary function indexe and clinical efficacy were compared between the two groups before and after treatment.Results Before treatment,there was no significant difference in CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)between the two groups;after treatment,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)immunity in the observation group were all higher than those in the control group,and CD8^(+)was lower than that in the control group,and the difference was statisti-cally significant(P<0.05).Before treatment,there was no significant difference in FVC and MVV between the two groups;after treatment,FVC and MVV in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The total effec-tive rate of the observation group was 94.12%,which was significantly higher than 73.53%of the control group,and the difference was statistically significant(P<0.05).Conclusion Pidotimod combined with house dust mite allergen preparation has significant clinical effect in the treatment of children with allergic rhinitis complicated with asthma,which can improve the immunity of patients and enhance lung function,it is worthy of clini-cal application.

关 键 词：匹多莫德 屋尘螨变应原制剂 变应性鼻炎 哮喘 

分 类 号：R725.6[医药卫生—儿科]