含鹅膏肽类毒素蘑菇中毒药物治疗研究进展  

Research progress on drug treatment of mushroom poisoning containing amanita peptide toxin

作　　者：徐红跃 姚群梅 钟加菊 余成敏 XU Hongyue;YAO Qunmei;ZHONG Jiaju;YU Chengmin(Department of emergency medicine,the People's Hospital of Chuxiong Yi Autonomous Prefecture,Chuxiong,Yunnan,675000,China)

机构地区：[1]楚雄彝族自治州人民医院急诊医学科,云南楚雄675000

出　　处：《当代医学》2022年第22期184-187,共4页Contemporary Medicine

基　　金：云南省重大科技专项(2018ZF009);云南省地方高校联合专项(202001BAO70001-046)。

摘　　要：90%以上的蘑菇中毒死亡事件是由含鹅膏肽类毒素蘑菇所致,目前该类蘑菇中毒尚无特效解毒药物。本文根据不同作用机制,将治疗药物分为胃肠道吸收抑制剂、肝细胞摄取抑制剂、抗氧化剂、RNAPⅡ结合抑制剂及中药5类,并对其作用机制、临床适应证、给药剂量进行综述,以期为临床治疗提供指导。More than 90%of the mushroom poisoning deaths were caused by mushrooms containing amanita toxin.At present,there is no specif-ic antidote for this type of mushroom poisoning.In this paper,according to the different mechanism of action,the therapeutic drugs were divided into gastrointestinal absorption inhibitors,liver cell uptake inhibitors,antioxidants,RNAPⅡbinding inhibitors and Traditional Chinese Medicine,the mechanism of action,clinical indications and dosage were reviewed in order to provide guidance for clinical treatment.

关 键 词：鹅膏肽类毒素 蘑菇中毒 中毒机制 药物治疗 

分 类 号：R595.7[医药卫生—内科学]