左卡尼汀联合重组人促红素对尿毒症合并肾性贫血患者红细胞比容及血红蛋白水平的影响  

Effects of L-carnitine combined with recombinant human erythropoietin in the treatment of uremia complicated with renal anemia

作　　者：杨旺华 YANG Wanghua(Department of Internal Medicine,Linchuan District People's Hospital,Fuzhou,Jiangxi,344100,China)

机构地区：[1]抚州市临川区人民医院内一科,江西抚州344100

出　　处：《当代医学》2022年第23期119-121,共3页Contemporary Medicine

摘　　要：目的探讨左卡尼汀联合重组人促红素(rHuEPO)治疗尿毒症合并肾性贫血的临床疗效及安全性。方法选取2019年2月至2021年2月本院收治的86例尿毒症合并肾性贫血患者作为研究对象,按随机数字表法分为两组,各43例。两组均行维持血液透析,对照组于血液透析后予以rHuEPO治疗,观察组在对照组基础上联合左卡尼汀治疗,比较两组临床疗效、血常规指标[血红蛋白(Hb)、红细胞比容(Hct)]、铁代谢指标[血清铁蛋白(SF)、转铁蛋白(TRF)、血清转铁蛋白饱和度(TSAT)]及不良反应发生情况。结果观察组治疗总有效率为95.35%,高于对照组的81.40%,差异有统计学意义(P<0.05)。治疗前,两组Hb、Hct水平比较差异无统计学意义;治疗后,两组Hb、Hct水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组SF、TRF、TSAT水平比较差异无统计学意义;治疗后,两组SF、TRF、TSAT水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论左卡尼汀联合rHuEPO可增强尿毒症合并肾性贫血治疗效果,改善患者血常规指标,纠正铁代谢异常,安全可靠,值得临床推广应用。Objective To investigate the clinical effect and safety of L-carnitine combined with recombinant human erythropoietin(rHuEPO)in the treatment of uremia complicated with renal anemia.Methods 86 patients with uremia complicated with renal anemia who were admitted to our hospital from February 2019 to February 2021 were selected as the research subjects,and they were divided into two groups according to the random number table method,with 43 cases in each group.Both groups were treated with maintenance hemodialysis,the control group was treated with rHuEPO after hemodialysis,and the observation group was treated with L-carnitine on the basis of the control group,the clinical efficacy,blood routine indexes(hemoglobin[Hb],hematocrit[Hct]),iron metabolism indexes(serum ferritin[SF],transferrin[TRF],serum transferrin saturation[TSAT])and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.35%,which was higher than 81.40%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of Hb and Hct between the two groups;after treatment,the levels of Hb and Hct in the two groups were higher than those before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of SF,TRF and TSAT between the two groups;after treatment,the levels of SF,TRF and TSAT in the two groups were higher than those before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion L-carnitine combined with rHuEPO can enhance the therapeutic effect of uremia complicated with renal anemia,improve blood routine indexes,and correct abnormal iron metabolism,which is safe and reliable,and worthy

关 键 词：尿毒症 肾性贫血 左卡尼汀 重组促红素 血常规指标 

分 类 号：R692.5[医药卫生—泌尿科学] R556[医药卫生—外科学]