盐酸氨溴索经纤维支气管镜肺泡灌洗治疗儿童难治性肺炎支原体肺炎的疗效及安全性分析  

Analysis on efficacy and safety of ambroxol hydrochloride by fiberoptic bronchoalveolar lavage in the treatment of refractory Mycoplasma pneumoniae pneumonia in children

作　　者：吴建武[1] 廖汉杰 WU Jianwu;LIAO Hanjie(Department of Pediatrics,Shiyan People's Hospital,Shenzhen 518108,Guangdong,China)

机构地区：[1]广东省深圳市宝安区石岩人民医院儿科,广东深圳518108

出　　处：《右江医学》2022年第8期577-581,共5页Chinese Youjiang Medical Journal

基　　金：深圳市宝安区科技计划项目(2021JD445)。

摘　　要：目的探讨盐酸氨溴索经纤维支气管镜肺泡灌洗治疗儿童难治性肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)的疗效及安全性。方法选取2019年1月至2021年6月在深圳市宝安区石岩人民医院进行治疗的80例难治性肺炎支原体肺炎患儿,随机分为观察组和对照组,各40例,两组均进行纤维支气管镜检查,对照组采用常规生理盐水灌洗治疗,观察组在对照组的基础上采用盐酸氨溴索灌洗治疗。对比两组临床疗效、住院时间及症状改善时间、炎症因子水平及不良反应。结果观察组的总有效率为95.0%,高于对照组的75.0%(χ^(2)=6.275,P<0.05);观察组住院时间及症状改善时间较对照组缩短(P<0.05);与治疗前1 d相比,治疗后14 d两组患儿血清白细胞介素-6(IL-6)、白细胞计数(WBC)、超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)水平及不良反应发生率均降低,且观察组低于对照组(P<0.05)。结论盐酸氨溴索经纤维支气管镜肺泡灌洗治疗儿童难治性肺炎支原体肺炎可有效提高患儿的临床疗效,减少不良反应发生,改善临床症状,降低炎症因子水平,减轻炎性反应。Objective To investigate the efficacy and safety of ambroxol hydrochloride by fiberoptic bronchoalveolar lavage in the treatment of refractory Mycoplasma pneumoniae pneumonia(MPP)in children.Methods 80 children with refractory MPP treated in Shiyan People's Hospital from January 2019 to June 2021 were randomly divided into observation group and control group,with 40 cases in each group.Both groups were examined by fiberoptic bronchoscopy,and then the control group were treated with conventional saline lavage,and the observation group were treated with ambroxol hydrochloride lavage on the basis of the control group.And then,clinical efficacy,length of hospital stay,symptom improvement time,inflammatory factors and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.0%,higher than that of the control group(75.0%)(χ^(2)=6.275,P<0.05).The length of hospital stay and symptom improvement time of the observation group were shorter than those of the control group(P<0.05).14 days after treatment,the levels of serum interleukin-6(IL-6),white blood cell(WBC),high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT)and the incidence of adverse reactions were lower than those at 1 day before treatment,and those of the observation group were lower than those of the control group(P<0.05).Conclusion Ambroxol hydrochloride by fiberoptic bronchoalveolar lavage can effectively improve the clinical efficacy of children with refractory Mycoplasma pneumoniae pneumonia,reduce adverse reactions,improve clinical symptoms,lower the levels of inflammatory factors,and alleviate the inflammatory reaction.

关 键 词：肺炎支原体肺炎 儿童 难治性 盐酸氨溴索 纤支镜肺泡灌洗 安全性 

分 类 号：R563.1[医药卫生—呼吸系统]