真穴与假穴针刺脑效应差异:一项基于fMRI的元分析  

The Difference of Brain Effect after Acupuncture at True And False Points:A Meta Analysis based on fMRI

作　　者：莫雨晓 郑水调 陈楚云 李丽霞 MO Yu-xiao;Zheng Shui-diao;CHEN Chu-yun;LI Li-xia(The Affiliated TCM Hospital of Guangzhou Medical University,510130 Guangzhou,Guangdong Province,China)

机构地区：[1]广州医科大学附属中医医院,广东广州510130

出　　处：《中国CT和MRI杂志》2022年第9期15-18,共4页Chinese Journal of CT and MRI

基　　金：全国中医药创新骨干人才培训项目(国中医药人教函[2019]128号);广东省省级科技计划(2017A030303004);广东省自然科学基金(2014A030309013)。

摘　　要：目的 评价针刺真穴和假穴后脑效应的差异。方法 检索国内期刊数据库,收集以脑功能磁共振成像(fMRl)为观察指标比较真穴针刺和假穴针刺后脑区活动变化的临床试验文献,采用SDM-PSI软件进行基于体素的全脑fMRI成像的元分析。结果 最终纳入9篇文献,共计18a名受试者,证实针刺真穴与假穴对比存在显著激活增强的脑区,分别是枕叶:左枕下回、BA19;颞叶:颞中回、BA21、BA37;额叶:右额上回、额中回、眶内侧回、眶回部分、BA10、BA11、BA45;顶叶:右顶叶上回、BA5,小脑、crusll,肼胝体,下纵束。结论 针刺真穴在大脑联络、高级神经功能、运动调节方面比假穴效应更显著。Objective To evaluate the difference of brain effect after acupunctu re at true and sham points.Methods To search the database of domestic journals and collect the clinical trial documents comparing the changes of brain activity after acupuncture at true acupoint and sham acupoint with functional magnetic resonance imaging(fMRI) as the observation index.SDM-PSI software was used for the meta-analysis of whole brain fMRI based on voxel.Results Finally,189 subjects in 9 literatures were included.It was confirmed that there were brain areas significantly activated and enhanced by acupunctu re at true acupoint compa red with the shame points,they were:occipital lobe:Left inferior occipital gyrus,BA19;temporal lobe:Middle temporal gyrus,BA21,BA37;frontal lobe:right superior frontal gyrus,middle frontal gyrus,medial orbital gyrus,part of orbital gyrus,BA10,BA11,BA45;pa rietal lobe:right superior parietal gyrus,BA5,ce rebellu m,crusii,corpus callosum,lower longitudinal tract.Conclusion The effect of acupuncture at the true acupoint is more significant than that at the shame points in brain connection,advanced nerve function and m otor regulation.

关 键 词：真穴 假穴 针刺 脑效应 脑功能磁共振成像 系统评价 

分 类 号：R277.7[医药卫生—中医学]