^(18)F-FDG PET/CT图像纹理分析用于甲状腺癌临床诊断价值探讨  

Value of ^(18)F-FDG PET/CT images texture analysis in the clinical diagnosis of thyroid cancer

作　　者：何涛 徐颖[1] 龚发阔 吴捷[1] 徐生洋 HE Tao;XU Ying;GONG Fa-kuo;Wu Jie;XU Sheng-yang(Panzhihua Central Hospital,Panzhihua 617067,Sichuan Province,China)

机构地区：[1]攀枝花市中心医院,四川攀枝花617067

出　　处：《中国CT和MRI杂志》2022年第9期33-35,共3页Chinese Journal of CT and MRI

摘　　要：目的 观察F-氟代脱氧葡萄糖(F-FDG)正电子发射断层显像与X射线断层扫描(PET/CT)图像纹理参数对甲状腺癌的诊断价值。方法 选取2017年4月至2019年3月于本院就诊的甲状腺癌患者49例作为观察组,另选取同期收治的甲状腺瘤患者42例作为对照组,两组患者均行F-FDG PET/CT显像,分析图像纹理参数(均值、方差、峰度、偏度、能量、熵值),记录病灶的最大标准摄取值(SUV)。结果 49例甲状腺癌患者中,39倒(79.59%)密度不均匀,34例(69.3%)表现为形态不规则,32例(65.30%)可观察到强化残圈,35例(71.43%)瘤体边缘模糊,28例(57.14%)出现明显钙化。两组患者均值、方差、峰度、偏度、能量比较差异无统计学意义(P>0.05);观察组患者SUV、熵值显著高于对照组(P<0.05);当SUV=4.92时,SUV诊断甲状腺癌的敏感性和特异性分别为82.17%、72.14%。当熵值=4.55时,熵值诊断的敏感性和特异性分别为77.50%、 74.62%。SUV与熵值联合诊断的曲线下面积(AUC)大于单一诊断。结论F-FDG PET/CT图像绞理特征参数-熵,对甲状腺癌具有一定的诊断价值,熵值与SUV联合应用可提高甲状腺癌诊断的敏感度和特异度。Objective To observe the diagnostic value of 18 F-fluorodeoxyglucose(F-FDG) positron emission tomography/computerized tomography(PET/CT) images texture parameters in thyroid cancer.Methods A total of 49 patients with thyroid cancer who were treated in the hospital from April 2017 to March 2019 were enrolled as observation group,while another 42 patients with thyroid tumors who were admitted during the same period were enrolled as control group.Both groups underwentF-FDG PET/CT imaging.The image texture parameters(mean,va riance,ku rtosis,skewness,energy,entropy) were analyzed.The maximum standard uptake value(SUV) of lesions was recorded.Results Among the 49 patients with thyroid cancer,there were 39(79.59%) cases with uneven density,34(69.39%) cases with irregular morphology,32(65.30%) cases with enhanced residual circle,35(71.43%) cases with blurred tumor edge and 28 cases(57.14%) cases with significant calcification.There were no significant differences in the mean,variance,kurtosis,skewness and energy between the two groups(P>0.05).SUVmax and entropy in observation group were significantly higher than those in control group(P<0.05).When SUVmax was 4.92,its sensitivity and specificity for diagnosis of thyroid cancer were 82.17% and 72.14%,respectively.When entropy value was 4.55,its sensitivity and specificity were 77.50% and 74.62%,respectively.The area under the curve(AUC) of SUVcombined with entropy was greater than that of single index.ConclusionF-FDG PET/CT image texture paramete r-entropy is of certain diagnostic value for thyroid cancer.The combined application of entro py value and SUVmax can improve diagnostic sensitivity and specificity for thyroid cancer.

关 键 词：正电子发射断层显像技术 X射计算机线断层扫描 ^(18)F-氟代脱氧葡萄糖 图像纹理分析 甲状腺癌 

分 类 号：R335.2[医药卫生—人体生理学]