吲哚化合物绿色高效的硫氰酸化反应  

Green and Highly Efficient Thiocyanation Reaction of Indole Compounds

作　　者：赵胤 殷珊 吴艳丹 刘瑞娜 倪广惠 ZHAO Yin;YIN Shan;WU Yandan;LIU Ruina;NI Guanghui(College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization,Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]云南中医药大学中药学院暨云南省南药可持续利用研究重点实验室,云南昆明650500

出　　处：《合成化学》2022年第8期628-633,共6页Chinese Journal of Synthetic Chemistry

基　　金：云南省教育厅科学研究基金资助项目(2022Y343);BK-云南省万人计划青年拔尖人才项目(30270108824)

摘　　要：本文报道了在温和绿色的条件下,以过氧化氢(H_(2)O_(2))作为氧化剂,进行吲哚化合物区域选择性硫氰酸化反应。结果表明:该反应体系中,无论是氮取代吲哚还是游离氨基吲哚均可获得较高的产率。产物2a~2o的结构经1 H NMR和^(13)C NMR表征。该方法的主要特点是反应条件温和,反应时间短,产率高。This article describes the regioselective thiocyanation of indole compounds with hydrogen peroxide(H_(2)O_(2))as an oxidant in a mild and green environment.In this system,both free indoles and N-substituted indoles can obtain the desired compounds in good yields.The structure of products 2a~2o were confirmed by 1 H NMR and ^(13)C NMR.The main characteristics of the method are mild reaction conditions,short reaction time and high yield.

关 键 词：吲哚 硫氰酸化 过氧化氢 硫氰酸铵 合成 

分 类 号：O626[理学—有机化学]