昆虫抗菌肽抗炎活性及基于信号通路抗炎机制的研究进展  

Research progress in anti-inflammatory activity of insect antimicrobial peptides and anti-inflammatory mechanism based on signal pathway

作　　者：崔会程 夏嫱 CUI Huicheng;XIA Qiang(Zhuhai Campus of Zunyi Medical University/Education and Innovation Base for Immunology Graduate Students in Guizhou Province,Zhuhai 519041,China)

机构地区：[1]遵义医科大学珠海校区/贵州省免疫学研究生创新研究基地,519041

出　　处：《天津医药》2022年第9期1002-1008,共7页Tianjin Medical Journal

基　　金：国家自然科学基金项目(32060127);贵州省科技计划项目(黔科合基础-ZK[2021]一般101);遵义医科大学学术新苗培养及创新探索专项项目(黔科合平台人才[2017]5733-069)。

摘　　要：昆虫抗菌肽是昆虫为抵御外界病原微生物感染产生的免疫活性物质的总称,其优异的抗炎活性使其具有广阔的应用前景。综述了不同种类昆虫抗菌肽的抗炎活性及可能涉及的信号通路,介绍了昆虫抗菌肽临床研究现状,以期为昆虫抗菌肽的应用研究提供文献参考。Insect antimicrobial peptides are the general name of immune active substances produced by insects to resist the infection of external pathogenic microorganisms.Their excellent anti-inflammatory activity makes them have broad application prospects.In this paper,the anti-inflammatory activities and their possible signaling pathways of different insect antimicrobial peptides were reviewed,and the current status of clinical research on insect antimicrobial peptides was introduced,in order to provide references for the application of insect antimicrobial peptides.

关 键 词：抗炎药(中药) 抗菌肽 昆虫 信号通路 抗炎活性 

分 类 号：R392.9[医药卫生—免疫学]