甲泼尼龙联合阿奇霉素治疗儿童存在肺实变的肺炎的临床分析  

Clinical analysis of methylprednisolone combined with azithromycin in the treatment of pneumonia with pulmonary consolidation in children

作　　者：李慧鹏 黄斌[1] 刘明[1] LI Huipeng;HUANG Bin;LIU Ming(Department of Pediatrics,Pingxiang People's Hospital,Pingxiang,Jiangxi,337000,China)

机构地区：[1]萍乡市人民医院儿科,江西萍乡337000

出　　处：《当代医学》2022年第19期144-147,共4页Contemporary Medicine

摘　　要：目的 探讨甲泼尼龙联合阿奇霉素治疗存在肺实变的肺炎患儿的临床效果。方法 选取2017年1月至2020年7月萍乡市人民医院收治的80例存在肺实变的肺炎患儿作为研究对象,按照随机数字表法分为对照组和观察组,每组40例。对照组采用阿奇霉素治疗,观察组采用甲泼尼龙联合阿奇霉素治疗。比较两组临床疗效、康复指标(退热时间、咳嗽消失时间、气促消失时间、肺啰音消失时间及住院时间)、治疗前后C反应蛋白(CRP)水平及不良反应发生情况。结果 观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组退热时间、咳嗽消失时间、气促消失时间、肺啰音消失时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗10 d后,两组CRP水平均低于治疗前,且观察组低于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论 采用甲泼尼龙联合阿奇霉素治疗存在肺实变的肺炎患儿可提高临床疗效,促进临床症状消退,降低炎症因子水平,缩短患儿住院时间,且不良反应少,安全性高,值得临床推广应用。Objective To explore the clinical effect of methylprednisolone combined with azithromycin in the treatment of children with pneumonia with pulmonary consolidation. Methods 80 children with pneumonia with pulmonary consolidation admitted to Pingxiang People’ s Hospital from January 2017 to July 2020 were selected as the research subjects, and they were divided into control group and observation group according to the random number table method, with 40 cases in each group. The control group was treated with azithromycin, while the observation group was treated with methylprednisolone combined with azithromycin. The clinical curative effect, rehabilitation indicators(antipyretic time, cough disappearance time, shortness of breath disappearance time, lung rales disappearance time and hospitalization time), the levels of C-reactive protein(CRP) before and after treatment, and the occurrence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). The time for antipyretic,disappearance of cough, disappearance of shortness of breath, disappearance of lung rales and hospitalization time in the observation group were all shorter than those in the control group, and the difference was statistically significant(P<0.05). After 10 d of treatment, CRP levels in both groups were lower than those before treatment, and the observation group was lower than that in control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Methylprednisolone combined with azithromycin in the treatment of children with pneumonia with pulmonary consolidation can improve the clinical efficacy, promote the regression of clinical symptoms, reduce the level of inflammatory factors, shorten the hospitalization time of children, and few adverse reactions and have high safety, it is worthy of clinical application.

关 键 词：存在肺实变的肺炎 甲泼尼龙 阿奇霉素 C反应蛋白 头晕 皮疹 

分 类 号：R725.6[医药卫生—儿科]