重组乙型肝炎疫苗联合乙肝免疫球蛋白阻断乙肝母婴传播的临床疗效  

Effect of recombinant hepatitis B vaccine combined with hepatitis B immunoglobulin in blocking mother to child transmission of hepatitis B

作　　者：贺昔春 严玲 彭晓华 HE Xichun;YAN Ling;PENG Xiaohua(Department of Obstetrics and Gynecology,Jiujiang NO.1 People's Hospital,Jiujiang,Jiangxi,332000,China)

机构地区：[1]九江市第一人民医院妇产科,江西九江332000

出　　处：《当代医学》2022年第20期68-70,共3页Contemporary Medicine

摘　　要：目的 探讨重组乙型肝炎疫苗联合乙肝免疫球蛋白阻断乙肝母婴传播的临床疗效。方法 选取2017年1月至2020年9月本院收治的102例乙肝表面抗原(HBsAg)携带的孕妇作为研究对象,采用随机数字表法分为对照组和研究组,每组51例。研究组分为HBsAg、乙型肝炎e抗原(HBeAg)双阳性组(n=29)和HBsAg阳性、HBeAg阴性组(n=22)。对照组给予单纯的重组乙型肝炎疫苗,研究组给予重组乙型肝炎疫苗联合乙肝免疫球蛋白,比较两组HBsAg阳性率及研究组乙型肝炎病毒(HBV)母婴传播阻断效果。结果 研究组HBsAg阳性率明显低于对照组(P<0.05)。HBsAg、HBeAg双阳性组的新生儿HBsAg阳性率明显高于HBsAg阳性、HBeAg阴性组(P<0.05)。结论 重组乙型肝炎疫苗联合乙肝免疫球蛋白对于阻断乙肝母婴传播临床效果显著,孕妇携带的HBeAg阳性能够使乙肝母婴传播阻断失败。Objective To explore the clinical effect of recombinant hepatitis B vaccine combined with hepatitis B immunoglobulin in interrupting mother to child transmission of hepatitis B. Methods 102 pregnant women with hepatitis B surface antigen(HBsAg) carriers in our hospital from January 2017 to September 2020 were selected as research subjects, and they were divided into control group and study group according to random number table method, with 51 cases in each group. The study group was divided into HBsAg, hepatitis B e antigen(HBeAg) double positive group(n=29) and HBsAg positive, HBeAg negative group(n=22). The control group was given simple recombinant hepatitis B vaccine, and the study group was given recombinant hepatitis B vaccine combined with hepatitis B immunoglobulin, the positive situation of HBsAg between the two groups and the blocking effect of hepatitis B virus(HBV) mother to child transmission in the study group were compared. Results The HBsAg positive rate of the study group was significantly lower than that of the control group(P<0.05), and the HBsAg positive rate of the newborns of the HBsAg and HBeAg positive groups was significantly higher than that of the HBsAg positive and HBeAg negative groups(P<0.05). Conclusion Recombinant hepatitis B vaccine combined with hepatitis B immunoglobulin has significant clinical effect on blocking mother to child transmission of hepatitis B,HBeAg positive pregnant women can make the interruption of mother to child transmission of hepatitis B fail.

关 键 词：乙肝母婴传播 乙型肝炎疫苗 乙肝免疫球蛋白 临床效果 

分 类 号：R714.251[医药卫生—妇产科学]