皮下注射及舌下含服特异性免疫治疗儿童过敏性支气管哮喘的临床疗效对比  

Comparison of clinical efficacy of subcutaneous injection and sublingual administration of specific immunotherapy in children with allergic bronchial asthma

作　　者：潘俊秀 周洁 彭云 张磊[2] PAN Junxiu;ZHOU Jie;PENG Yun;ZHANG Lei(Department of Child Allergy,Chenzhou Children's Hospital,Chenzhou,Hunan,431000,China;Medical Department,Chenzhou First People's Hospital,Chenzhou,Hunan,431000,China)

机构地区：[1]郴州市儿童医院儿童过敏反应科,湖南郴州431000 [2]郴州市第一人民医院医务部,湖南郴州431000

出　　处：《当代医学》2022年第20期71-73,共3页Contemporary Medicine

基　　金：郴州市研发及技术创新课题(ZDYF2020062)。

摘　　要：目的 探讨皮下注射及舌下含服特异性免疫治疗儿童过敏性支气管哮喘的临床疗效。方法 选取2019年1月至2020年1月本院收治的120例过敏性支气管哮喘患儿作为研究对象,按照随机数字表法分为观察组和对照组,各60例。观察组采用舌下含服特异性免疫治疗,对照组采用皮下注射治疗,比较两组临床疗效、鼻部状态、不良反应发生情况。结果 观察组治疗总有效率为93.33%,略高于对照组的90.00%,但两组比较差异无统计学意义。治疗前,两组鼻部鼻塞、鼻痒、喷嚏、流涕评分比较差异无统计学意义;治疗后,两组鼻部鼻塞、鼻痒、喷嚏、流涕评分均低于治疗前,差异有统计学意义(P<0.05),两组间各评分比较差异无统计学意义。观察组治疗期间不良反应发生率为14.67%,低于对照组的41.67%,差异有统计学意义(P<0.05)。结论 皮下注射与舌下含服特异性免疫治疗均有良好的疗效,但舌下特异性免疫治疗的不良反应发生率更低,临床疗效更好。Objective To investigate the clinical efficacy of subcutaneous injection and sublingual administration of specific immunotherapy in children with allergic bronchial asthma. Methods 120 children with allergic bronchial asthma admitted to our hospital from January 2019 to January2020 were selected as the research subjects, and they were randomly divided into observation group and control group according to random number table method, with 60 cases in each group. The observation group was treated with sublingual specific treatment, and the control group was treated with subcutaneous injection. The clinical efficacy, nasal state and adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 93.33%, which was slightly higher than 90.00% in the control group, but there was no significant difference between the two groups. Before treatment, there was no significant difference in the scores of nasal congestion, nasal itching, sneezing and runny nose between the two groups;after treatment, the scores of nasal congestion, nasal itching, sneezing and runny nose in two groups were lower than those before treatment, and the difference was statistically significant(P<0.05);there was no statistically significant difference in the scores of nasal state between the two groups. The incidence of adverse reactions during treatment in the observation group was 14.67%, which was lower than41.67% in the control group, and the difference was statistically significant(P<0.05). Conclusion Both of subcutaneous injection and sublingual administration have good therapeutic effect, but the clinical adverse reaction rate of sublingual specific treatment is low, and the clinical efficacy is more significant.

关 键 词：舌下含服 特异性免疫治疗 皮下注射 儿童过敏性支气管哮喘 

分 类 号：R725.6[医药卫生—儿科]