Cubic multi-ions-doped Na_(2)TiO_(3) nanorod-like coatings:Structure-stable,highly efficient platform for ions-exchanged release to immunomodulatory promotion on vascularized bone apposition  

作　　者：Dongmei Yu Bo Li Meng Yu Shuo Guo Zheng Guo Yong Han 

机构地区：[1]a State Key Laboratory for Mechanical Behavior of Materials,Xi’an Jiaotong University,Xi’an,710049,Shaanxi,China [2]Department of Orthopaedics,Tangdu Hospital,Fourth Military Medical University,Xi’an,710038,Shaanxi,China

出　　处：《Bioactive Materials》2022年第12期72-90,共19页生物活性材料（英文）

基　　金：the financial support from the National Natural Science Foundation of China(Grant number 51631007 and 51971171).

摘　　要：The dissolution-derived release of bioactive ions from ceramic coatings on metallic implants,despite improving osseointegration,renders a concern on the interfacial breakdown of the metal/coating/bone system during longterm service.Consequently,persistent efforts to seek alternative strategies instead of dissolution-derived activation are pressingly carrying out.Inspired by bone mineral containing ions as Ca2+,Mg2+,Sr2+and Zn2+,here we hydrothermally grew the quadruple ions co-doped Na2TiO3 nanorod-like coatings.The co-doped ions partially substitute Na+in Na2TiO3,and can be efficiently released from cubic lattice via exchange with Na+in fluid rather than dissolution,endowing the coatings superior long-term stability of structure and bond strength.Regulated by the coatings-conditioned extracellular ions,TLR4-NFκB signalling is enhanced to act primarily in macrophages(MΦs)at 6 h while CaSR-PI3K-Akt1 signalling is potentiated to act predominately since 24 h,triggering MΦs in a M1 response early and then in a M2 response to sequentially secrete diverse cytokines.Acting on endothelial and mesenchymal stem cells with the released ions and cytokines,the immunomodulatory coatings greatly promote Type-H(CD31hiEmcnhi)angiogenesis and osteogenesis in vitro and in vivo,providing new insights into orchestrating insoluble ceramics-coated implants for early vascularized osseointegration in combination with long-term fixation to bone.

关 键 词：Nanorod-like coating Ion doping Sodium titanate Immunomodulation Angiogenesis OSSEOINTEGRATION 

分 类 号：TB383[一般工业技术—材料科学与工程] R543[医药卫生—心血管疾病]