Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development  

作　　者：Hong Niu Haichang Li Ya Guan Xin Zhou Zhongguang Li Serana Li Zhao Peng Chen Tao Tan Hua Zhu Valerie Bergdall Xuehong Xu Jianjie Ma Jianjun Guan 

机构地区：[1]Department of Mechanical Engineering and Materials Science,Washington University in St.Louis,St.Louis,MO,63130,USA [2]Institute of Materials Science and Engineering,Washington University in St.Louis,St.Louis,MO,63130,USA [3]Department of Surgery,Davis Heart and Lung Research Institute,The Ohio State University,Columbus,OH,43210,USA [4]Laboratory of Cell Genetics and Developmental Biology,Shaanxi Normal University College of Life Sciences,Xi’an,710062,China [5]Department of Veterinary Preventive Medicine,University Laboratory Animals Resources,The Ohio State University,Columbus,OH,43210,USA

出　　处：《Bioactive Materials》2022年第12期104-115,共12页生物活性材料（英文）

基　　金：National Institutes of Health (R01AG056919).

摘　　要：MG53 is an essential component of the cell membrane repair machinery,participating in the healing of dermal wounds.Here we develop a novel delivery system using recombinant human MG53(rhMG53)protein and a reactive oxygen species(ROS)-scavenging gel to treat diabetic wounds.Mice with ablation of MG53 display defective hair follicle structure,and topical application of rhMG53 can promote hair growth in the mg53/mice.Cell lineage tracing studies reveal a physiological function of MG53 in modulating the proliferation of hair follicle stem cells(HFSCs).We find that rhMG53 protects HFSCs from oxidative stress-induced apoptosis and stimulates differentiation of HSFCs into keratinocytes.The cytoprotective function of MG53 is mediated by STATs and MAPK signaling in HFSCs.The thermosensitive ROS-scavenging gel encapsulated with rhMG53 allows for sustained release of rhMG53 and promotes healing of chronic cutaneous wounds and hair follicle development in the db/db mice.These findings support the potential therapeutic value of using rhMG53 in combination with ROS-scavenging gel to treat diabetic wounds.

关 键 词：Diabetic wound healing hair follicle stem cell MG53 ROS-Scavenging hydrogel Controlled drug delivery 

分 类 号：R587.1[医药卫生—内分泌]