Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg-Ca-Zn-Ag alloy to inhibit bacterial infection and promote bone regeneration  

作　　者：Bo Yuan Hewei Chen Rui Zhao Xuangeng Deng Guo Chen Xiao Yang Zhanwen Xiao Antoniac Aurora Bita Ana Iulia Kai Zhang Xiangdong Zhu Antoniac Vasile Iulian Shen Hai Xingdong Zhang 

机构地区：[1]National Engineering Research Center for Biomaterials,Sichuan University,Chengdu,610064,China [2]College of Biomedical Engineering,Sichuan University,Chengdu,610064,China [3]Sichuan Provincial Orthopedic Hospital,Chengdu,610041,China [4]Faculty of Materials Science and Engineering,University Politehnica of Bucharest,060042,Bucharest,Romania [5]Academy of Romanian Scientists,050094,Bucharest,Romania

出　　处：《Bioactive Materials》2022年第12期354-367,共14页生物活性材料（英文）

基　　金：Inter-Governmental S&T Cooperation Project Between China and Romania(2018LMNY003);Sichuan Science and Technology Program(2019JDTD0008,2021YFS0020);ChinaPostdoctoral Science Foundation (2021M692316, 2020TQ0218).

摘　　要：The improved corrosion resistance, osteogenic activity, and antibacterial ability are the key factors for promoting the large-scale clinical application of magnesium (Mg)-based implants. In the present study, a novel nanocomposite coating composed of inner magnesium hydroxide, middle graphene oxide, and outer hydroxyapatite (Mg(OH)_(2)/GO/HA) is constructed on the surface of Mg-0.8Ca-5Zn-1.5Ag by a combined strategy of hydrothermal treatment, electrophoretic deposition, and electrochemical deposition. The results of material characterization and electrochemical corrosion test showed that all the three coatings have high bonding strength, hydrophilicity and corrosion resistance. In vitro studies show that Mg(OH)2 indeed improves the antibacterial activity of the substrate. The next GO and GO/HA coating procedures both promote the osteogenic differentiation of MC3T3-E1 cells and show no harm to the antibacterial activity of Mg(OH)2 coating, but the latter exhibits the best promoting effect. In vivo studies demonstrate that the Mg alloy with the composite coating not only ameliorates osteolysis induced by bacterial invasion but also promotes bone regeneration under both normal and infected conditions. The current study provides a promising surface modification strategy for developing multifunctional Mg-based implants with good corrosion resistance, antibacterial ability and osteogenic activity to enlarge their biomedical applications.

关 键 词：Mg alloy Composite coating Corrosion resistance Antibacterial ability Osteogenic activity 

分 类 号：R318[医药卫生—生物医学工程] TB3[医药卫生—基础医学]