抗苗勒管激素和性激素水平在围绝经期骨质疏松妇女中的变化及预测价值  

Changes and predictive value of anti-Müllerian hormone and sex hormones in perimenopausal women with osteoporosis

作　　者：滕晓晶[1] 王智毅 徐冰 赵洪灿[1] 项国谦[1] TENG Xiao-Jing;WANG Zhi-Yi;XU Bing(Department of Clinical Laboratory,Hangzhou First People's Hospital,Hangzhou,Zhejiang 310000,China)

机构地区：[1]杭州市第一人民医院检验科,浙江杭州310000 [2]杭州市妇产科医院检验科,浙江杭州310008

出　　处：《中国妇幼保健》2022年第15期2880-2883,共4页Maternal and Child Health Care of China

基　　金：浙江省医药卫生科技计划项目(2019KY528);浙江省杭州市科技发展计划项目(20191203B92)。

摘　　要：目的 检测抗苗勒管激素(AMH)和性激素水平在围绝经期骨质疏松妇女中的变化,分析AMH和性激素预测围绝经期妇女骨质疏松的价值。方法 选取2020年6—12月杭州市第一人民医院妇产科收治的157例围绝经期妇女为研究对象,按照骨质疏松的诊断标准将其分为骨质疏松组(57例)、骨量减少组(48例)及骨量正常组(52例)。检测3组围绝经期妇女血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))、AMH及甲状旁腺激素(PTH)水平。比较3组围绝经期妇女血清性激素和AMH水平,采用Pearson相关系数分析各指标间的相关性。结果 骨质疏松组围绝经期妇女血清AMH、FSH、LH、E_(2)及PTH水平分别为(0.25±0.15)ng/ml、(29.12±5.00)IU/L、(15.81±2.98)IU/L、(16.70±3.63)pg/ml及(46.60±6.07)pg/ml;骨量减少组围绝经期妇女血清AMH、FSH、LH、E_(2)及PTH水平分别为(0.57±0.39)ng/ml、(26.42±5.04)IU/L、(10.34±2.92)IU/L、(25.10±5.11)pg/ml及(40.72±3.05)pg/ml;骨量正常组围绝经期妇女血清AMH、FSH、LH、E_(2)及PTH水平分别为(0.89±0.98)ng/ml、(20.39±2.72)IU/L、(7.66±2.73)IU/L、(36.64±12.93)pg/ml及(34.38±3.53)pg/ml。3组围绝经期妇女血清AMH、FSH、LH、E_(2)及PTH水平比较差异均有统计学意义(F=111.215,51.734,103.754,173.134,143.873,均P<0.05)。骨质疏松组围绝经期妇女血清AMH、E_(2)水平均显著低于骨量减少组,两组比较差异均有统计学意义(t=-5.717,P<0.05;t=-9.817,P<0.05);骨质疏松组围绝经期妇女血清FSH、LH及PTH水平均显著高于骨量减少组,两组比较差异均有统计学意义(t=2.746,P<0.05;t=9.456,P<0.05;t=6.092,P<0.05)。骨量减少组围绝经期妇女血清AMH、E_(2)水平均显著低于骨量正常组,两组比较差异均有统计学意义(t=-2.112,P<0.05;t=-5.779,P<0.05);骨量减少组围绝经期妇女血清FSH、LH及PTH水平均显著高于骨量正常组,两组比较差异均有统计学意义(t=7.524,P<0.05;t=4.743,P<0.05;t=9.574,P<0.05)。Pearson相关�Objective To analyze the changes and predictive value of anti-Müllerian hormone(AMH) and sex hormones in perimenopausal women with osteoporosis.Methods From June to December in 2020, one hundred and fifty-seven perimenopausal women treated in Department of Gynecology and Obstetrics, Hangzhou First People’s Hospital were selected as study object, then the perimenopausal women were divided into osteoporosis group(fifty-seven cases), osteopenia group(forty-eight cases), and normal bone mass group(fifty-two cases) according to the diagnostic criteria of osteoporosis. The levels of serum follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E), AMH, and parathyroid hormone(PTH) were detected, the levels of sex hormones and AMH in the three groups were compared, Pearson correlation coefficient was used to analyze the correlations between each indicator.Results The levels of serum AMH, FSH, LH, E, and PTH in osteoporosis group were(0.25±0.15) ng/ml,(29.12±5.00) IU/L,(15.81±2.98) IU/L,(16.70±3.63) pg/ml, and(46.60±6.07) pg/ml, respectively;the levels of serum AMH, FSH, LH, E, and PTH in osteopenia group were(0.57±0.39) ng/ml,(26.42±5.04) IU/L,(10.34±2.92) IU/L,(25.10±5.11) pg/ml, and(40.72±3.05) pg/ml, respectively;the levels of serum AMH, FSH, LH, E, and PTH in normal bone mass group were(0.89±0.98) ng/ml,(20.39±2.72) IU/L,(7.66±2.73) IU/L,(36.64±12.93) pg/ml, and(34.38±3.53) pg/ml, respectively.There were statistically significant differences in the levels of serum AMH, FSH, LH, E, and PTH among the three groups(F=111.215, 51.734, 103.754, 173.134, 143.873, P<0.05).The levels of serum AMH and Ein osteoporosis group were statistically significantly lower than those in osteopenia group(t=-5.717, P<0.05;t=-9.817, P<0.05);the levels of serum FSH, LH, and PTH in osteoporosis group were statistically significantly higher than those in osteopenia group(t=2.746, P<0.05;t=9.456, P<0.05;t=6.092, P<0.05).The levels of serum AMH and Ein osteopenia group were statistically significantly lower than

关 键 词：围绝经期 骨质疏松 性激素 抗苗勒管激素 

分 类 号：R592[医药卫生—老年医学]