糖尿病肾脏病阳虚证的临床特征与炎症因子相关性研究  

Correlation of Clinical Features with Inflammatory Factors in Diabetic Kidney Disease of Yang Deficiency Syndrome

作　　者：吴巧茹 王耀献[2] 杨涵雯[1] 闫润泽 王晓娜[1] 张佳乐 姜伟民 孙卫卫[1] WU Qiao-Ru;WANG Yao-Xian;YANG Han-Wen;YAN Run-Ze;WANG Xiao-Na;ZHANG Jia-Le;JIANG Wei-Min;SUN Wei-Wei(Dongzhimen Hospital,Beijing University of Chinese medicine,Beijing 100700,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学,北京100029

出　　处：《广州中医药大学学报》2022年第8期1723-1727,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：北京中医药大学青年教师项目(编号:2017-JYB-JS-075)。

摘　　要：【目的】探讨糖尿病肾脏病(DKD)阳虚证的临床特征及其与炎症因子的相关性。【方法】收集106例DKD患者的临床资料,分析比较阳虚证与非阳虚证患者的临床特征与炎症因子水平。【结果】(1)阳虚证患者与非阳虚证患者相比,尿素氮、血肌酐、24 h尿蛋白总量水平升高,肾小球滤过率(eGFR)、血总蛋白、血白蛋白水平下降,差异均有统计学意义(P<0.05或P<0.01)。(2)几丁质酶样蛋白40(YKL-40)、肿瘤坏死因子受体1(TNFR-1)、成纤维细胞生长因子23(FGF-23)与尿素氮、血肌酐、24 h尿蛋白总量呈正相关,与eGFR呈负相关,差异均有统计学意义(P<0.01)。(3)阳虚证患者与非阳虚证患者相比,YKL-40、TNFR-1、FGF-23水平均升高,其中两证型间TNFR-1比较,差异有统计学意义(P<0.01)。【结论】DKD阳虚证患者与非阳虚证患者相比,肾功能更差,相关炎症因子水平更高。Objective To investigate the correlation of clinical features with inflammatory factors in diabetic kidney disease(DKD)with yang deficiency syndrome.Methods Clinical data of 106 patients with DKD were collected,and then the clinical features and inflammatory factor levels in patients with yang deficiency syndrome and in patients with non-yang deficiency syndrome were compared.Results(1)Patients with yang deficiency syndrome had higher levels of urea nitrogen,serum creatinine and 24-hour total urine protein,and had lower levels of estimated glomerular filtration rate(eGFR),blood total protein and blood albumin than the patients with non-yang deficiency syndrome,and the differences were statistically significant(P<0.05 or P<0.01).(2)Chitinase-like protein 40(YKL-40),tumor necrosis factor receptor 1(TNFR-1)and fibroblast growth factor 23(FGF-23)were positively correlated with urea nitrogen,serum creatinine and 24-hour total urine protein,and were negatively correlated with eGFR,the differences all being statistically significant(P<0.01).(3)The levels of YKL-40,TNFR-1 and FGF-23 were all increased in patients with yang deficiency syndrome and in patients with non-yang deficiency syndrome,and the difference of TNFR-1 was statistically significant between the two groups(P<0.01).Conclusion DKD patients with yang deficiency syndrome have poorer renal function and higher levels of associated inflammatory factors than DKD patients with non-yang deficiency syndrome.

关 键 词：糖尿病肾脏病 阳虚证 临床特征 肾功能 炎症因子 

分 类 号：R259.872[医药卫生—中西医结合]