温阳健脾益气活血法治疗初诊2型糖尿病的临床研究  

Clinical Study of Therapy of Warming Yang and Invigorating Spleen,Replenishing Qi and Activating Blood for the Treatment of Newly-diagnosed Type 2 Diabetes Mellitus

作　　者：谢炎烽 杨丽平 陈壮娜 阮永队 XIE Yan-Feng;YANG Li-Ping;CHEN Zhuang-Na;RUAN Yong-Dui(Southeast Central Hospital of Dongguan,Dongguan 523700 Guangdong,China;Dongguan Guangcheng People’s Hospital,Dongguan 523129 Guangdong,China)

机构地区：[1]东莞市东南部中心医院,广东东莞523700 [2]东莞市莞城医院,广东东莞523129

出　　处：《广州中医药大学学报》2022年第8期1769-1774,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20202222)。

摘　　要：【目的】探究温阳健脾益气活血法治疗初诊2型糖尿病脾肾阳虚证患者的临床疗效。【方法】将90例初诊2型糖尿病脾肾阳虚证患者随机分为对照组和观察组,每组各45例。对照组给予盐酸二甲双胍片治疗,观察组给予中医温阳健脾益气活血法(包括中药内服及针刺和艾灸)治疗,疗程为3个月。观察2组患者治疗前后中医证候积分及相关胰岛素功能指标的变化情况,并评价2组患者的临床疗效和安全性。【结果】(1)治疗3个月后,观察组的总有效率为93.33%(42/45),对照组为77.78%(35/45);组间比较,观察组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的口干渴饮、多尿、大便干结、倦怠无力等各项中医证候积分均较治疗前明显降低(P<0.05),且观察组的降低作用均明显优于对照组,差异均有统计学意义(P<0.01)。(3)治疗后,2组患者的胰岛素敏感指数(ISI),空腹胰岛素(FINS)及餐后2 h胰岛素(2hINS)水平均较治疗前明显改善(P<0.05),且观察组的改善作用均明显优于对照组,差异均有统计学意义(P<0.05或P<0.01)。(4)治疗过程中,2组患者均未发生肝肾功能受损,心电图检查也均显示正常。【结论】温阳健脾益气活血法治疗初诊2型糖尿病脾肾阳虚证患者疗效确切,能有效改善临床症状和胰岛素功能,且安全性高。Objective To investigate the clinical efficacy of therapy of warming yang and invigorating spleen,replenishing qi and activating blood in treating patients with newly-diagnosed type 2 diabetes mellitus(T2DM)and differentiated as deficiency of spleen and kidney yang syndrome.Methods Ninety newly-diagnosed T2DM patients with deficiency of spleen and kidney yang syndrome were randomly divided into the control group and the observation group,with 45 cases in each group.The control group was treated with Metformin Hydrochloride Tablets,while the observation group was treated with traditional Chinese medicine(TCM)therapy including oral use of Chinese medicine,acupuncture and moxibustion which has the actions of warming yang and invigorating spleen,replenishing qi and activating blood.The treatment for the two groups lasted for a period of 3 months.The changes in the TCM syndrome scores and insulin function related indexes in the two groups before and after treatment were observed,and the clinical efficacy and safety of the two groups were also evaluated.Results(1)After 3 months of treatment,the total effective rate of the observation group was 93.33%(42/45)and that of the control group was 77.78%(35/45).The intergroup comparison showed that the efficacy of the observation group was significantly superior to that of the control group,and the difference was statistically significant(P<0.05).(2)After treatment,the scores of TCM syndromes of dry mouth and thirst,polyuria,dry stools and fatigue were significantly decreased in both groups compared with those before treatment(P<0.05),and the effect on lowering the TCM syndrome scores in the observation group was significantly superior to that in the control group,the differences being statistically significant(P<0.01).(3)After treatment,the insulin sensitivity index(ISI),fasting insulin(FINS)and 2-hour postprandial insulin(2hINS)levels of both groups were significantly improved compared with those before treatment(P<0.05),and the improvement in the observation group was signi

关 键 词：2型糖尿病 脾肾阳虚证 温阳健脾 益气活血 胰岛素功能 临床疗效 安全性 

分 类 号：R259.871[医药卫生—中西医结合]