大柴胡汤加减治疗中风后不寐少阳阳明热证的临床疗效观察  

Clinical Observation on Modified Da Chaihu Decoction for the Treatment of Post-stroke Insomnia with Shaoyang-Yangming Heat Syndrome

作　　者：梁露 肖纯 LIANG Lu;XIAO Chun(Graduate School of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Shenzhen Bao’an Traditional Chinese Medicine Hospital Group,the Affiliated Hospital of Guangzhou University of Chinese Medicine,Shenzhen 518100 Guangdong,China)

机构地区：[1]广州中医药大学研究生院,广东广州510405 [2]广州中医药大学附属宝安中医院,深圳市宝安中医院(集团),广东深圳518100

出　　处：《广州中医药大学学报》2022年第7期1505-1510,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省名中医传承工作室建设项目(编号:粤中办函[2020]1号)。

摘　　要：【目的】观察大柴胡汤加减治疗中风(脑卒中)后不寐(失眠)少阳阳明热证的临床疗效。【方法】将78例中风后不寐少阳阳明热证患者随机分为治疗组和对照组,每组各39例。2组患者均给予脑卒中后常规基础治疗,在此基础上,治疗组给予大柴胡汤加减治疗,对照组给予口服阿普唑仑片治疗,疗程为2周。观察2组患者治疗前后匹兹堡睡眠质量指数(PSQI)评分及脑卒中专用生活质量量表(SS-QOL)评分的变化情况,并评价2组患者的临床疗效。【结果】(1)连续治疗2周后,治疗组的总有效率为87.2%(34/39),对照组为69.2%(27/39),组间比较,治疗组的临床疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的PSQI评分均较治疗前明显降低(P<0.05),且治疗组对PSQI评分的降低作用明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的SS-QOL评分均较治疗前明显提高(P<0.05),且治疗组对SS-QOL评分的提高作用明显优于对照组,差异有统计学意义(P<0.05)。【结论】大柴胡汤加减治疗中风后不寐少阳阳明热证患者疗效确切,可有效改善患者睡眠质量,提高患者生活质量。Objective To observe the clinical efficacy of modified Da Chaihu Decoction for the treatment of poststroke insomnia with shaoyang-yangming heat syndrome.Methods Seventy-eight patients with post-stroke insomnia of shaoyang-yangming heat syndrome were randomly divided into the treatment group and the control group,39 cases in each group.Patients of the two groups were given post-stroke conventional basic treatment,and additionally,the treatment group was given modified Da Chaihu Decoction and the control group was given Alprazolam Tablets orally.The treatment for both groups lasted for 2 weeks.The changes in the Pittsburgh Sleep Quality Index(PSQI)scores and Stroke-Specific Quality of Life Scale(SS-QOL)scores were observed in the two groups before and after treatment,and the clinical efficacy of the two groups was evaluated after treatment.Results(1)After treatment for 2 continuous weeks,the overall effective rate of the treatment group was 87.2%(34/39)and that of the control group was 69.2%(27/39),and the intergroup comparison showed that the clinical efficacy of the treatment group was significantly superior to that of the control group,the difference being statistically significant(P<0.05).(2)After treatment,the PSQI scores of patients in both groups were significantly decreased compared with those before treatment(P<0.05),and the effect on lowering the PSQI scores in the treatment group was superior to that in the control group,the difference being statistically significant(P<0.05).(3)After treatment,the SS-QOL scores of patients in both groups were significantly increased compared with those before treatment(P<0.05),and the effect on increasing the SS-QOL scores in the treatment group was superior to that in the control group,the difference being statistically significant(P<0.05).Conclusion The modified Da Chaihu Decoction exerts certain effect in treating patients with post-stroke insomnia of shaoyang-yangming heat syndrome,which is effective on improving the quality of sleep and enhancing the quality of life

关 键 词：大柴胡汤 脑卒中 失眠 中风后不寐 少阳阳明热证 匹兹堡睡眠质量指数(PSQI)评分 脑卒中专用生活质量量表(SS-QOL)评分 

分 类 号：R255.2[医药卫生—中医内科学] R256.23[医药卫生—中医学]