皮肤微生态与皮肤疾病研究进展  

Research Progress in Skin Microecology and Skin Diseases

作　　者：杨沛峥 程宇豪 汤晓雷 管运才 胡一桥[1] YANG Peizheng;CHENG Yuhao;TANG Xiaolei;GUAN Yuncai;HU Yiqiao(School of Medicine,Nanjing University,Nanjing 210093,China;Jun Skincare Co.Ltd.,Nanjing 210033,China;Jiangsu Zhongtian Pharma,Taizhou 225316,China)

机构地区：[1]南京大学医学院,江苏南京210093 [2]江苏君隽生物科技有限公司,江苏南京210033 [3]江苏中天药业有限公司,江苏泰州225316

出　　处：《药学进展》2022年第7期545-553,共9页Progress in Pharmaceutical Sciences

基　　金：国家重点研发计划(No.2017YFA0205400);国家自然科学基金(No.81872811)。

摘　　要：皮肤是人体最大的器官,其结构从内到外依次为皮下组织、真皮层和表皮层。皮肤表面及腺体等部位定植着众多微生物,统称为皮肤微生物组。不同微生物其组成和分布在一定范围内维持动态平衡,并通过增殖、分泌等方式与宿主的皮肤及免疫系统进行相互调节,构成了皮肤微生态系统。当皮肤菌群失调时,会引发微生态紊乱,导致疾病的发生。通过微生态角度进行治疗,不仅能有效减少病症,还可避免细菌耐药性扩散等情况。综述了皮肤微生态相关的近期研究成果,并着重介绍皮肤微生物与皮肤疾病的关联,以及微生态治疗在皮肤疾病中的应用,旨在为相关研究提供参考。The skin is the largest organ of the human body.From inside to outside,it is composed by subcutaneous tissue,dermis and epidermis.Numerous microorganisms colonize on the skin surface and glands,collectively referred to as the skin microbiome.The composition and distribution of different microorganisms maintain a dynamic balance within a certain range,and they interact with the host’s skin and immune system through proliferation and secretion,forming a skin micro ecosystem.When the skin flora is out of balance,it will lead to microecological disorder and disease.Treatment from the perspective of microecology can not only effectively reduce the disease,but also avoid the spread of bacterial drug resistance.This paper reviews the recent research results related to skin microecology,and focuses on the relationship between skin microorganisms and skin diseases,as well as the application of microecological therapy in skin diseases,so as to provide reference for related research.

关 键 词：皮肤微生态 动态平衡 微生态治疗 皮肤疾病 

分 类 号：R322.99[医药卫生—人体解剖和组织胚胎学]