Klotho蛋白与儿童及新生儿生长关系的研究进展  

Research progress on the relationship between Klotho and the growth of children and newborns

作　　者：曹梦圆 程亚颖[1] 周冉 Cao Mengyuan;Cheng Yaying;Zhou Ran(Department of Pediatrics,Hebei General Hospital,Shijiazhuang 050051,China)

机构地区：[1]河北省人民医院儿科,石家庄050051

出　　处：《中国综合临床》2022年第4期369-373,共5页Clinical Medicine of China

基　　金：河北省科技厅重点研发计划卫生健康创新专项(21377783D)。

摘　　要：Klotho是一种与衰老相关的基因,该基因编码的跨膜蛋白在肾脏中高度表达,在大脑、甲状旁腺和垂体等组织中亦有表达。其胞外结构域裂解、脱落形成可溶性Klotho蛋白,作为循环激素发挥作用,因此可以在血液、脑脊液和尿液中检测到。越来越多的研究表明,Klotho蛋白是生长激素(growth hormone,GH)-胰岛素样生长因子1(insulin-like growth factor 1,IGF1)轴复杂调节过程中的重要角色。Klotho蛋白与GH-IGF1轴之间的相互作用是双向的,其互相调节,进而调控儿童正常的线性生长。此外,Klotho蛋白还可通过不同的途径对胎儿及新生儿生长发育产生一定的影响,其作用机制尚不十分明确。Klotho is a gene associated with aging,the transmembrane protein encoded by this gene is highly expressed in the kidney,and is also expressed in tissues such as the brain,parathyroid and pituitary glands.The extracellular domain of Klotho can also be cleaved and shed to form soluble Klotho,which acts as a circulating hormone and can be detected in blood,cerebrospinal fluid,and urine.More and more studies have shown that Klotho protein plays an important role in the complex regulation of growth hormone(GH)-insulin-like growth factor 1(IGF1)axis.The interaction between Klotho protein and GH-IGF1 axis is bidirectional,which regulates each other,and then regulates the normal linear growth of children.In addition,Klotho protein can also affect the growth and development of fetus and newborn through different ways,and its mechanism is not very clear.

关 键 词：KLOTHO 生长激素 胰岛素样生长因子1 线性生长 小于胎龄儿 

分 类 号：R72[医药卫生—儿科]