围绝经期和绝经后女性绝经症状与日常认知功能的相关性研究  

Study on the relationship between menopausal symptoms and everyday cognition in perimenopausal and postmenopausal women

作　　者：黄文俊 耿露露 蒋素素 李长滨[1] 陶敏芳[1] Huang Wenjun;Geng Lulu;Jiang Susu;Li Changbin;Tao Minfang(Department of Gynecology and Obstetrics,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200030,China)

机构地区：[1]上海交通大学附属第六人民医院妇产科,上海200030

出　　处：《中华生殖与避孕杂志》2022年第6期589-594,共6页Chinese Journal of Reproduction and Contraception

摘　　要：目的探讨围绝经期和绝经后女性绝经症状与日常认知功能的相关性。方法采用横断面研究,分析2018年10月至2020年10月期间初次就诊于上海交通大学附属第六人民医院妇产科绝经门诊的314例患者的临床资料。采用改良Kupperman绝经指数(Kupperman menopausal index,KMI)量表评估绝经症状及其严重程度;简短版日常认知功能(everyday cognition,ECog)量表评估日常认知功能。多元线性回归分析围绝经期和绝经后女性绝经症状与日常认知功能的相关性。结果314例患者ECog分数为1.50±0.49。KMI分数为12.67±7.88,74.8%(235/314)患者有绝经症状,其中34.7%(109/314)有中重度绝经症状。相比无绝经症状患者(ECog得分:1.27±0.29),有绝经症状的患者ECog得分更高(轻度症状组ECog得分:1.48±0.47,P=0.005;中重度症状组ECog得分:1.69±0.55,P<0.001)。相关性分析表明,KMI的5个症状(潮热出汗、失眠、情绪波动、抑郁和疲乏)均与日常认知功能下降相关(P<0.001)。多元线性回归分析显示潮热出汗[β=0.060,95%置信区间(confidence interval,CI)=0.002~0.117,P=0.043]、抑郁(β=0.163,95%CI=0.073~0.253,P<0.001)和疲乏(β=0.138,95%CI=0.071~0.205,P<0.001)症状仍与日常认知功能下降相关。结论潮热出汗、抑郁和疲乏症状是围绝经期和绝经后女性日常认知功能下降的独立危险因素。Objective To evaluate the relationship between menopausal symptoms and everyday cognition in perimenopausal and postmenopausal women.Methods A cross-sectional study was used to analyze the clinical data of 314 women who first visited the menopausal clinic of Department of Gynecology and Obstetrics of Shanghai Jiao Tong University Affiliated Sixth People's Hospital from October 2018 to October 2020.The modified Kupperman menopausal index(KMI)scale was used to assess the prevalence and severity of menopausal symptoms,and a short version of everyday cognition(ECog)scale was used to evaluate everyday cognition.Multiple linear regression was used to analyze the relationship between menopausal symptoms and everyday cognition in perimenopausal and postmenopausal women.Results The ECog score of 314 patients was 1.50±0.49.The score of KMI was 12.67±7.88,74.8%(235/314)of the patients had menopausal symptoms,and 34.7%(109/314)had moderate to severe menopausal symptoms.Compared with asymptomatic patients(ECog scores:1.27±0.29),symptomatic patients had higher ECog scores(mild symptoms group:1.48±0.47,P=0.005;moderate to severe symptoms group:1.69±0.55,P<0.001).Correlation analysis showed that the five symptoms of KMI(hot flashes/sweating,insomnia,irritability,melancholia and fatigue)were associated with the decline of everyday cognition(P<0.001).Multiple linear regression analysis showed that the symptoms of hot flashes/sweating[β=0.060,95%confidence interval(CI)=0.002-0.117,P=0.043],melancholia(β=0.163,95%CI=0.073-0.253,P<0.001)and fatigue(β=0.138,95%CI=0.071-0.205,P<0.001)were still associated with the decline of everyday cognition.Conclusion The symptoms of hot flashes/sweating,melancholia and fatigue are independent risk factors for the decline of everyday cognition in perimenopausal and postmenopausal women.

关 键 词：围绝经期 绝经症状 日常认知功能 相关性 

分 类 号：R711.75[医药卫生—妇产科学]