Toll样受体是连接过敏进程和卫生假说的桥梁  

Toll-like receptors link atopic march and hygiene hypothesis

作　　者：马陈惠 何权 周林福 Ma Chenhui;He Quan;Zhou Linfu(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院呼吸与危重症医学科,南京210029

出　　处：《中华结核和呼吸杂志》2022年第8期803-808,共6页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家重点研发计划(2018YFC1313600);国家自然科学基金重点国际(地区)合作研究项目(81820108001);国家自然科学基金项目(81670029);江苏省医学重点人才项目(ZDRCA2016018);江苏省333高层次人才工程中青年领军人才项目(BRA2019078);江苏省社会发展重点研发专项(BE2015651)。

摘　　要：过敏进程揭示罹患特应性皮炎的婴幼儿后期易发生食物过敏、过敏性鼻炎和哮喘。卫生假说强调个人卫生和环境越干净,哮喘和变态反应(过敏症)的发病率反而越高。现认为,模式识别受体Toll样受体(TLR)是连接固有免疫和适应性免疫的桥梁,在炎症和免疫性疾病中起重要作用。越来越多的证据表明,TLR参与过敏进程的发生发展,并且连接过敏进程与卫生假说,有望成为治疗哮喘和过敏症的新靶标。The atopic march reveals that infants with atopic dermatitis are prone to food allergy,allergic rhinitis and asthma later in life.The hygiene hypothesis holds that the cleaner the personal hygiene and environment,the higher the incidence rate of asthma and allergy.It is believed that Toll like receptors(TLRs)are the bridge between innate immunity and adaptive immunity,playing an important role in inflammatory and immune diseases.More and more evidence shows that TLRs,involved in the pathophysiology of atopic march,connect atopic march with hygiene hypothesis as a potential therapeutic target for asthma and allergy.

关 键 词：特应性皮炎 卫生假说 个人卫生 过敏进程 适应性免疫 模式识别受体 TOLL样受体 固有免疫 

分 类 号：R593.1[医药卫生—内科学]