经典名方旋覆代赭汤历史沿革探析  

Historical evolution of Xuanfu Daizhe Decoction

作　　者：李莎莎[1] 侯酉娟[1] 张磊[1] 董燕[1] 刘思鸿[1] 李斌[1] 张楚楚 杨晓宁 游蓉丽 许海玉[3,4] 李兵[3] LI Sha-sha;HOU You-juan;ZHANG Lei;DONG Yan;IU Si-hong;LI Bin;ZHANG Chu-chu;YANG Xiao-ning;YOU Rong-li;XU Hai-yu;LI Bing(Istiuate of Information on Traditional Chinse Medicine,China Academy of Chinese Medical Seiences,Beijing 100700,China;Bejing Zhendong Guangming Pharmaceutical Research Insiue Co.,Itd.,Bejing 100085.China;Instiute of Chinese Materin Medica,China Acudemy of Chinese Medical Sciences,Beijing 100700,China;Key Laboratory for Quality Research and Evaluation of Tradional Chinese Medicine,National Medical Produets Administration,China Academy of Chinese Medical Seinces,Beijing 100700.China)

机构地区：[1]中国中医科学院中医药信息研究所,北京100700 [2]北京振东光明药物研究院有限公司,北京100085 [3]中国中医科学院中药研究所,北京100700 [4]中国中医科学院国家药品监督管理局中药研究与评价重点实验室,北京100700

出　　处：《中国中药杂志》2022年第15期4033-4041,共9页China Journal of Chinese Materia Medica

基　　金：中央级公益性科研院所基本科研业务费专项(ZZ120304,ZZ140306)。

摘　　要：经典名方旋覆代赭汤首见于东汉张仲景《伤寒论》,原方由旋覆花、甘草、人参、生姜、代赭石、半夏、大枣7味药组成,用于治疗伤寒发汗误治后心下痞硬、噫气不除。旋覆代赭汤的历代医籍记载和论述丰富,后世医家对该方进行了广泛的临床应用,不断拓展了该方的方义及其功能主治。该文全面收集整理了经典名方旋覆代赭汤的古今文献记载,从处方来源、方剂组成、药物剂量、药味炮制、临床应用、方义方解、煎煮法等方面对旋覆代赭汤进行系统的梳理和分析,发现历代记载的旋覆代赭汤药味组成及其炮制方法较为一致,临床处方用量呈现逐渐减少的趋势,古代临床中主要用于治疗反胃、呕吐、呃逆、便秘等疾病,而现代临床主要用于治疗反流性食管炎、胃炎等消化系统疾病,古今临床应用广泛。通过对旋覆代赭汤历史沿革的探析和考证,可以明确该方的药味组成、处方剂量、药味炮制、方义衍变及煎煮方法,为经典名方旋覆代赭汤的复方制剂研发提供思路。Xuanfu Daizhe Decoction,first seen in Zhang Zhongjing′s Treatise on Cold Damage Diseases,was composed of seven medicinal materials:Inulae Flos,Glycyrrhizae Radix,Ginseng Radix,Zingiberis Rhizoma Recens,Haematitum,Pinelliae Rhizoma and Jujubae Fructus.It was used to treat gastric fullness and hardness and belching due to the wrong treatment of typhoid fever and sweating.With detailed records and description in ancient medical books,Xuanfu Daizhe Decoction was widely adopted in clinical practice by physicians of later generations,which expanded its main therapeutic functions.By comprehensive collation of ancient and modern literature on Xuanfu Daizhe Decoction,this paper systematically explored the historical evolution of the prescription from the source,composition,dosage,processing,clinical application,function interpretation and decocting method.It was found that the composition and processing method of the prescription in the past dynasties were relatively consistent,and there was a gradual decrease in dosage in clinical application.In ancient times,Xuanfu Daizhe Decoction was mainly used to treat nausea,vomiting,hiccups,constipation,etc.,while modern clinicians mainly used it for digestive diseases such as reflux esophagitis and gastritis.Through the analysis and textual research,the composition,dosage,processing,function evolution and decocting method of this prescription were determined,which provided reference for the research and development of compound preparations of Xuanfu Daizhe Decoction.

关 键 词：旋覆代赭汤 经典名方 临床应用 历史沿革 文献分析 

分 类 号：R289.5[医药卫生—方剂学]