早期检测蒽环类药物心脏毒性的影像学研究进展  

Advances in imaging research on the early detection of anthracycline cardiotoxicity

作　　者：王璐霞 郝新忠[1] 王若楠[1] 李思进[1] Wang Luxia;Hao Xinzhong;Wang Ruonan;Li Sijin(Department of Nuclear Medicine,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院核医学科,太原030001

出　　处：《国际放射医学核医学杂志》2022年第5期298-303,共6页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金(81901785)。

摘　　要：随着治疗手段的进步,肿瘤患者的生存率及生存时间明显改善,但肿瘤治疗相关心功能不全严重威胁着肿瘤幸存者的健康,其中蒽环类药物(ANTs)引起的心脏毒性极其常见,并可导致不可逆的心脏损伤。ANTs心脏毒性的早期发现和及时治疗对于心脏功能的恢复至关重要,因此早期检测心脏毒性具有重要的临床意义。笔者主要探讨有助于早期检测ANTs心脏毒性的影像学新方法,包括超声心动图心肌应变成像、心脏磁共振心肌应变成像和心肌组织定量成像以及PET/CT显像,以期为临床早期发现ANTs心脏毒性提供有价值的信息。With the advancement of treating methods,the survival rate and survival time of tumor patients have improved significantly,but the cancer therapeutics-related cardiac dysfunction seriously threatens the health of tumor survivors,among which the cardiotoxicity caused by anthracyclines(ANTs)is extremely common and can lead to irreversible heart damage.Early detection and timely treatment of cardiotoxicity caused by ANTs are essential for the recovery of cardiac function,so early detection of cardiotoxicity is of great clinical importance.The author focuses on new imaging methods that may help to detect the cardiotoxicity caused by ANTs early,including myocardial strain imaging by echocardiography,myocardial strain imaging and quantification imaging of myocardial tissue by cardiac magnetic resonance and PET/CT imaging,in order to provide valuable information for early clinical detection of cardiotoxicity caused by ANTs.

关 键 词：正电子发射断层显像术 体层摄影术 X线计算机 早期检测 心脏毒性 蒽环类药物 影像技术 

分 类 号：R969[医药卫生—药理学]