基于树状大分子材料构建的纳米载药体系用于肿瘤靶向治疗的研究进展  

Research progress of nano-drug delivery systems based on dendrimer materials for tumor targeted therapy

作　　者：陈倩倩 张金赫 Chen Qianqian;Zhang Jinhe(Graduate School of Guangzhou University of Chinese Medicine,Guangzhou 510006,China;Department of Nuclear Medicine,General Hospital of Southern Theater Command,Guangzhou 510010,China)

机构地区：[1]广州中医药大学研究生院,广州510006 [2]南部战区总医院核医学科,广州510010

出　　处：《国际放射医学核医学杂志》2022年第5期304-308,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：广州市科技计划项目(201904010126)。

摘　　要：近年来兴起的树状大分子材料的结构可控,且其与细胞膜和各种活性药物分子具有独特的相互作用,因此成为构建纳米载药体系的优良材料,并在肿瘤靶向治疗领域得到了广泛研究。树状大分子作为具有良好生物相容性的纳米分子,可与肿瘤靶向分子偶联,从而将活性药物分子特异性递送到肿瘤组织,如此可最大限度地提高药物的靶向性,并减少其对非靶组织的毒性作用。笔者就近年来基于树状大分子材料构建的纳米载药体系用于肿瘤靶向治疗的研究进展进行综述。Dendrimer materials emerging in recent years have become excellent materials for constructing nano-drug delivery systems due to their controllable structures and unique interactions with cell membranes and various active drug molecules,and have been widely studied in the field of tumor targeted therapy.As nanomolecules with good biocompatibility,dendrimers can be conjugated to tumor-targeting molecules to specifically deliver active drug molecules to tumor tissues,which can maximize drug targeting and reduce toxic effects on non-target tissues.In this paper,the recently research progress of nano-drug delivery systems based on dendrimer materials for tumor targeted therapy is reviewed.

关 键 词：树状聚合物 纳米复合物 放射性同位素 载药体系 靶向治疗 

分 类 号：R943[医药卫生—药剂学]