全身糖脂代谢的关键调节剂:法尼酯X受体(FXR)  

A key regulator of whole-body glucose and lipid metabolism:Farnesoid X receptor(FXR)

作　　者：王定保 丁雪莲 蒋祖环 李玲 杨岚[2] 叶啟发[2,3] WANG Dingbao;DING Xuelian;JIANG Zuhuan;LI Ling;YANG Lan;YE Qifa(Clinical Central Laboratory,The First People’s Hospital of Xiaogan City,Xiaogan 432100,Hubei,China;Zhongnan Hospital of Wuhan University,Institute of Hepatobiliary Diseases of Wuhan University,Transplant Center of Wuhan University,&Hubei Key Laboratory of Medical Technology on Transplantation,Wuhan 430071,Hubei,China;The 3rd Xiangya Hospital of Central South University&Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology,Changsha 410013,Hunan,China)

机构地区：[1]孝感市第一人民医院临床中心实验室,湖北孝感432100 [2]武汉大学中南医院/武汉大学肝胆疾病研究院/武汉大学移植医学中心/移植医学技术湖北省重点实验室,湖北武汉430071 [3]中南大学湘雅三医院/卫生部移植医学工程技术研究中心,湖南长沙410013

出　　处：《武汉大学学报（医学版）》2022年第5期859-863,共5页Medical Journal of Wuhan University

基　　金：武汉大学医学腾飞计划——“转化医学、医学+医学平台建设项目”(临床医学)(编号:TFLC2018003)。

摘　　要：法尼酯X受体(FXR)是一种核受体,活化后会引起能量代谢相关途径的改变。它不仅在肝脏组织中作为一种胆汁酸受体存在,还发挥肝脏、肌肉和脂肪组织中能量代谢的调节作用。不仅作用于它所存在的局部组织,还通过血液循环影响全身组织。研究表明,FXR不仅调节胆汁酸的代谢,还调节脂肪和烃类物质的代谢。作为代谢过剩疾病,如糖尿病的治疗靶点,FXR被广泛研究。本文拟就近几年FXR激活及其在糖脂代谢中的作用作一综述,为进一步治疗有关疾病选择药物靶点提供有效依据。Farnesoid X receptor(FXR) is a nuclear receptor that, when activated, causes changes in the pathways involved in energy metabolism. It not only routinely presents as a bile acid receptor in liver tissue, but also acts as a regulator of energy metabolism in the liver, muscle and adipose tissue. It acts not only on the local tissue it is present in, but also on the whole body. Studies have shown that FXR not only regulates the metabolism of bile acids, but also regulates the metabolism of fats and hydrocarbons. FXR has been extensively studied as a candidate for the treatment of metabolic disorders, such as diabetes. This article intends to review the role of FXR activation and its role in glucose and lipid metabolism in recent years, providing an effective basis for further treatment of related diseases to select drug targets.

关 键 词：法尼酯X受体 糖代谢 脂代谢 

分 类 号：R58[医药卫生—内分泌]