神经干细胞重编程及其应用的研究进展  

Progress of neural stem cell reprogramming and its application

作　　者：曾琳 陆彦邑 严博文 何庆华 冯正权 高丹丹 刘媛 Zeng Lin;Lu Yanyi;Yan Bowen;He Qinghua;Feng Zhengquan;Gao Dandan;Liu Yuan(Laboratory of Military Medical Equipment,Daping Hospital,Army Medical University;Laboratory of Special Environmental War Wound Prevention and Treatment,Daping Hospital,Army Medical University)

机构地区：[1]陆军军医大学大坪医院军队卫生装备与器材研究室,重庆400042 [2]特殊环境战伤防治研究室,重庆400042

出　　处：《重庆医科大学学报》2022年第7期853-856,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:81772066)。

摘　　要：神经干细胞重编程技术可将体细胞生成具有疾病相关表型的成熟人类神经元,为神经障碍疾病的细胞治疗带来前景。笔者就神经干细胞重编程的调控因素、提高重编程效率以及应用于神经障碍疾病建模等方面的研究进展进行综述。Neural stem cells(NSCs)reprogramming technology can generate mature human neurons with disease-related phenotypes from somatic cells,bringing a prospect for cell therapy of neurological disorders.In this paper,the regulatory factors of NSCs reprogramming,the improvement of reprogramming efficiency and the application in the modeling of neurological disorders are reviewed.

关 键 词：神经干细胞 重编程 神经障碍 

分 类 号：R320[医药卫生—人体解剖和组织胚胎学]