祛疣洗剂湿敷患处治疗女性尖锐湿疣患者对Th1/Th2平衡及院外复发率的影响  

Effect of Condyloma Acuminatum Wet Compress with Anti-wart Lotion on Th1/Th2 Balance and Out-of-Hospital Recurrence Rate in Female Patients

作　　者：郭玉冰 王远 GUO Yu-bing;WANG Yuan(Department of Dermatology,The First Affiliated Hospital,Eastern Hospital,Medical College of Xi'an Jiaotong University,Xi'an Shaanxi 710061)

机构地区：[1]西安交通大学第一附属医院东院皮肤科,陕西西安710061 [2]西安市第五医院皮肤科,陕西西安710008

出　　处：《医学临床研究》2022年第7期961-964,968,共5页Journal of Clinical Research

基　　金：陕西省自然科学基础研究计划一般项目(面上)(2021JM-572)。

摘　　要：【目的】探讨祛疣洗剂湿敷患处治疗女性尖锐湿疣患者对辅助性T细胞1(Th1)/辅助性T细胞2(Th2)平衡及复发率的影响。【方法】选取2020年9月至2021年9月西安交通大学第一附属医院东院皮肤科收治的74例女性尖锐湿疣患者,抽签随机分为观察组和对照组,每组37例。两组入院后均行二氧化碳激光治疗,观察组创面愈合后使用祛疣洗剂湿敷患处,对照组使用咪喹莫特乳膏涂抹患处。4周为1个疗程,两组均连续治疗2个疗程。比较两组临床疗效、复发率、不良反应发生率及治疗前后Th1/Th2指标[干扰素-γ(IFN-γ)、白介素-4(IL-4)、白介素-10(L-10)、Th1/Th2]、炎症反应指标[超敏C反应蛋白(hs-CPR)、肿瘤坏死因子-α(TNF-α)]、血管内皮生长因子(VEGF)、人乳头瘤病毒(HPV)-DNA。【结果】观察组患者治疗总有效率显著高于对照组,复发率显著低于对照组,差异有统计学意义(P<0.05);两组治疗前IFN-γ、IL-4、IL-10、Th1/Th2比较,差异无统计学意义(P>0.05);与治疗前比较,两组治疗后IL-4、IL-10显著降低,IFN-γ、Th1/Th2显著升高,差异有统计学意义(P<0.05);但两组治疗后IFN-γ、IL-4、IL-10、Th1/Th2比较,差异无统计学意义(P>0.05)。两组治疗前VEGF、hs-CPR、TNF-α、HPV-DNA比较,差异无统计学意义(P>0.05);与治疗前比较,两组治疗后VEGF、hs-CPR、TNF-α、HPV-DNA均显著降低,差异有统计学意义(P<0.05);两组治疗后VEGF、hs-CPR、TNF-α比较,差异无统计学意义(P>0.05);观察组治疗后HPV-DNA显著低于对照组治疗后,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】祛疣洗剂湿敷用于治疗女性尖锐湿疣疗效较好,可改善患者免疫功能,减轻炎症反应,且无明显不良反应,值得临床推广应用。【Objective】To investigate the effect of condyloma acuminata treated with Anti-wart lotion on the balance of helper T cell 1(Th1)/helper T cell 2(Th2)and the recurrence rate.【Methods】A total of 74 female patients with condyloma acuminatum treated in the department of dermatology,east hospital,the First Affiliated Hospital of Xi'an Jiaotong University from September 2020 to September 2021 were randomly divided into observation group and control group by lot,with 37 cases in each group.Both groups were treated with carbon dioxide laser after admission.The observation group was wet applied with Anti-wart lotion after wound healing,and the control group was smeared with imiquimod cream.Four weeks was a course of treatment,and both groups were treated for two consecutive courses.The clinical efficacy,recurrence rate,adverse reaction rate and Th1/Th2 indexes before and after treatment were compared between the two groups[interferon-γ(IFN-γ),interleukin-4(IL-4),interleukin-10(IL-10),Th1/Th2],inflammatory response indicators[high sensitivity C-reactive protein(HS CPR),tumor necrosis factor-α(TNF-α)],vascular endothelial growth factor(VEGF)and human papillomavirus(HPV)-DNA.【Results】The total effective rate of the observation group was significantly higher than that of the control group,and the recurrence rate was significantly lower than that of the control group(P<0.05);Before treatment,IFN-γ,IL-4,IL-10 and Th1/Th2 of both groups were compared,and the difference was not statistically significant(P>0.05);Compared with those before treatment,IL-4 and IL-10 in the two groups decreased significantly after treatment,and IFN-γ,Th1/Th2 increased significantly,the difference was statistically significant(P<0.05);But after treatment,IFN-γ,IL-4,IL-10 and Th1/Th2 in both groups were compared,and the difference was not statistically significant(P>0.05).Before treatment,VEGF,hs-CPR,TNF-α and HPV-DNA was compared,and the difference was not statistically significant(P>0.05);Compared with those before treatment,VEGF,H

关 键 词：尖锐湿疣/药物疗法 女(雌)性 TH1细胞 TH2细胞 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]