扩散加权成像相关参数诊断肾小球肾炎的价值及其与肾脏病理损害严重程度的关系  

Value of Diffusion Weighted Imaging in the Diagnosis of Glomerulonephritis and its Relationship with the Severity of Renal Pathological Damage

作　　者：张磊[1] 李卓[1] ZHANG Lei;LI Zhuo(Department of Radiology,Affiliated Hospital of Yan'an University,Yan'an Shaanxi 716000)

机构地区：[1]延安大学附属医院放射科,陕西延安716000

出　　处：《医学临床研究》2022年第7期977-980,共4页Journal of Clinical Research

基　　金：陕西省科学技术研究发展计划项目(2016SF-043)。

摘　　要：【目的】探讨扩散加权成像(DWI)相关参数诊断肾小球肾炎的价值及其与肾脏病理损害严重程度间的关系。【方法】本院收治的56例肾小球肾炎患者为观察组,选择同期入院体检健康者56例为对照组。统计两组入院时一般资料,肾功能指标[血肌酐(SCr)、尿素氮(BUN)]、合并疾病、肾皮质和肾髓质表现弥散系数(ADC)值等。采用受试者工作特征(ROC)曲线分析DWI相关参数对肾小球肾炎的诊断价值。根据Katafuchi肾病评分系统评价观察组肾脏病理损害严重程度,并对不同病理损害严重程度患者肾皮质和肾髓质ADC值进行比较,分析其与肾脏病理损害严重程度的相关性。【结果】两组SCr、BUN水平、年龄及性别构成比比较,差异无统计学意义(P>0.05);观察组肾皮质ADC值、肾髓质ADC值均低于对照组(P<0.05)。经ROC曲线分析发现肾皮质ADC值、肾髓质ADC值对肾小球肾炎有一定诊断价值,曲线下面积分别为0.787、0.739。56例肾小球肾炎患者中,有20例(35.71%)为肾脏无病理损害,纳为正常组;26例(46.43%)为轻度损害,纳为轻度组;10例(17.86%)为中度损害,纳为中度组;无重度损害者。正常组肾皮质ADC值、肾髓质ADC值均高于轻度组、中度组(P<0.05),且随着肾脏病理损害程度加重而降低;正常组Katafuchi损害积分均低于轻度组、中度组(P<0.05),随肾脏病理损害程度加重而增加。经Pearson检验,肾皮质和肾髓质ADC值与病理积分呈负相关(P<0.05)。【结论】DWI相关参数对肾小球肾炎有一定的诊断价值,其与肾脏病理损害程度有一定相关性。【Objective】To investigate the value of diffusion weighted imaging(DWI)in the diagnosis of glomerulonephritis and its relationship with the severity of renal pathological damage.【Methods】A total of 56 patients with glomerulonephritis in our hospital were selected as the observation group,and 56 healthy subjects were selected as the control group.The general data of the two groups at admission,renal function[serum creatinine(SCR),urea nitrogen(BUN)],combined diseases,renal cortex and renal medulla performance diffusion coefficient(ADC)values,etc.were collected.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of DWI related parameters in glomerulonephritis.The severity of renal pathological damage in the observation group was evaluated according to Katafuchi nephropathy scoring system,and ADC values of renal cortex and renal medulla in patients with different severity of pathological damage were compared to analyze their correlation with the severity of renal pathological damage.【Results】There was no significant difference in the levels of SCR,BUN,age and sex ratio between the two groups(P>0.05);The ADC values of renal cortex and renal medulla in the observation group were lower than those in the control group(P<0.05).The ROC curve analysis showed that the ADC values of renal cortex and renal medulla had certain diagnostic value for glomerulonephritis,and the areas under the curve were 0.787 and 0.739 respectively.Among the 56 patients with glomerulonephritis,20 patients(35.71%)had no pathological damage to the kidney and were considered as normal group;26 cases(46.43%)were mild damage,and were classified as mild group;10 cases(17.86%)were moderate damage,and were classified as moderate group;No severe damage.The ADC values of renal cortex and renal medulla in the normal group were higher than those in the mild group and the moderate group(P<0.05);Katafuchi damage score in the normal group was lower than that in the mild group and moderate group(P<0.05).By Pearson test

关 键 词：肾小球肾炎/影像诊断 弥散磁共振成像/方法 肾/病理生理学 

分 类 号：R692.31[医药卫生—泌尿科学]