冠心病患者血清脂联素、白蛋白、层粘蛋白水平及其临床意义  

Serum Adiponectin,Albumin and Laminin Levels in Patients with Coronary Heart Disease and their Clinical Significance

作　　者：王海强 王磊[2] WANG Hai-qiang;WANG Lei(No.986 Hospital of the Chinese People's Liberation Army Air Force,Xi'an Shaanxi 719000)

机构地区：[1]中国人民解放军空军第九八六医院心血管内科,陕西西安719000 [2]西安市中心医院心内科,陕西西安710003

出　　处：《医学临床研究》2022年第7期999-1001,共3页Journal of Clinical Research

摘　　要：【目的】探讨冠心病(CHD)患者血清脂联素(APN)、白蛋白(ALB)、层粘蛋白(LN)水平及其临床意义。【方法】选取2018年3月至2020年4月中国人民解放军空军第九八六医院收治的117例CHD患者(观察组),并选取同期健康体检的89例健康志愿者(对照组),并根据Gensini积分将117例CHD患者分为轻度病变组(43例)、中度病变组(38例)、重度病变组(36例)。采用酶联免疫吸附(ELISA)法检测血清APN、ALB、LN水平,Pearson相关性分析CHD患者血清APN、ALB、LN水平与Gensini积分的相关性。【结果】与对照组比较,观察组血清APN、ALB水平明显降低,血清LN水平明显升高(P<0.05)。血清APN、ALB水平由高至低为轻度、中度、重度病变组,血清LN水平由高至低为重度、中度、轻度,组间比较差异有统计学意义(P<0.05)。CHD患者Gensini积分为(43.64±13.76)分,血清APN、ALB水平与Gensini积分呈负相关,LN水平与Gensini积分呈正相关(P<0.05)。【结论】CHD患者血清中APN、ALB呈低表达,LN呈高表达,可能与CHD疾病严重程度有关。【Objective】To investigate the levels of serum adiponectin(APN),albumin(ALB)and laminin(LN)in patients with coronary heart disease(CHD)and their clinical significance.【Methods】A total of 117 patients with CHD(observation group)admitted to the No.986 Hospital of the Air Force of the Chinese People's Liberation Army Air Force from March 2018 to April 2020 were selected,and 89 healthy volunteers(control group)who underwent physical examination in the same period were selected.117 patients with CHD were divided into mild disease group(43 cases),moderate disease group(38 cases)and severe disease group(36 cases)according to Gensini score.Enzyme linked immunosorbent assay(ELISA)was used to detect the levels of serum APN,ALB,LN.Pearson correlation analysis was used to analyze the correlation between the levels of serum APN,ALB,LN and Gensini score in patients with CHD.【Results】Compared with the control group,the levels of serum APN and ALB in the observation group decreased significantly,and the level of serum LN increased significantly(P<0.05).The levels of serum APN and ALB from high to low were mild,moderate and severe lesion groups,and the levels of serum LN from high to low were severe,moderate and mild.The difference between the groups was statistically significant(P<0.05).The Gensini score of CHD patients was(43.64±13.76),the levels of serum APN and ALB were negatively correlated with Gensini score,and the level of LN was positively correlated with Gensini score(P<0.05).【Conclusion】The low expression of APN and ALB and high expression of LN in serum of CHD patients may be related to the severity of CHD.

关 键 词：冠心病 脂联素/血液 白蛋白类/血液 黏蛋白类/血液 

分 类 号：R541.4[医药卫生—心血管疾病]