紫癜性肾炎患儿血清FiB、D-D、sFlt-1、vWF水平变化及其临床意义  

Clinical Significance of Serum FiB,D-D,SFLT-1 and vWF Levels Changes in Children with Purpura Nephritis

作　　者：张迎旭[1] 樊淑娟 ZHANG Ying-xu;FAN Shu-juan(Baoji Maternal and Child Health Hospital,Baoji Shaanxi 721000)

机构地区：[1]宝鸡市妇幼保健院,陕西宝鸡721000 [2]陕西省咸阳市彬州市人民医院,陕西咸阳713500

出　　处：《医学临床研究》2022年第7期1033-1036,共4页Journal of Clinical Research

摘　　要：【目的】探讨紫癜性肾炎(HSPN)患儿血清纤维蛋白原(FiB)、D-二聚体(D-D)、可溶性血管内皮生长因子受体-1(sFlt-1)和血管性血友病因子(vWF)水平变化及其临床意义。【方法】以两院收治的HSPN患儿56例作为HSPN组,过敏性紫癜(HSP)患儿79例作为HSP组,同期健康体检儿童52例作为对照组,检测并比较各组FiB、D-D、sFlt-1、vWF及肾损伤指标24 h尿蛋白排泄量(24hUPE)、尿素氮(BUN)、血肌酐(SCr)水平;采用Pearson相关法分析FiB、D-D、sFlt-1、vWF与肾损伤指标的相关性。【结果】HSPN组FiB、D-D、sFlt-1、vWF明显高于HSP组和对照组(P<0.05),HSP组FiB、D-D、sFlt-1、vWF明显高于对照组(P<0.05)。HSPN组24hUPE明显高于HSP组和对照组(P<0.05),HSP组24hUPE水平与对照组比较,差异无统计学意义(P>0.05);各组BUN、SCr水平比较,差异无统计学意义(P>0.05)。Pearson相关性分析结果显示,HSPN组患儿FiB与24hUPE无明显相关性(r=0.188,P>0.05),D-D、sFlt-1、vWF与24hUPE均呈正相关(r=0.491、0.502、0.546,P<0.05)。【结论】HSPN患儿血清FiB、D-D、sFlt-1、vWF水平明显升高,其可能与HSP早期肾脏损伤有关。【Objective】To investigate the changes of serum fibrinogen(FiB),D-dimer(D-D),soluble vascular endothelial growth factor receptor-1(sFlt-1)and von willebrand factor(vWF)levels and their clinical significance in children with henoch-schonlein purpura nephritis(HSPN).【Methods】A total of 56 children with HSPN admitted to our hospital were selected as the HSPN group,79 children with henoch schonlein Purpura(HSP)were selected as the HSP group,and 52 healthy children were selected as the control group.The levels of FiB,D-D,sFlt-1,vWF,24 h urinary protein excretion(24hUPE),urea nitrogen(BUN)and serum creatinine(SCr)in all groups were detected and compared.Pearson correlation method was used to analyze the correlation of FiB,D-D,sFlt-1 and vWF with renal injury indexes.【Results】The FiB,D-D,sFlt-1 and vWF levels in the HSPN group were significantly higher than those in the HSP group and the control group(P<0.05),and the levels of FiB,D-D,sFlt-1 and vWF in the HSP group were significantly higher than those in the control group(P<0.05).The level of 24hUPE in the HSPN group was significantly higher than that in the HSP group and the control group(P<0.05),while there was no statistical difference in 24hUPE level between the HSP group and the control group(P>0.05).There were no statistical differences in BUN and SCr levels among all groups(P>0.05).Pearson correlation analysis showed that there was no significant correlation between FiB and 24hUPE in the HSPN group(r=0.188,P>0.05),while D-D,sFlt-1 and vWF were positively correlated with 24hUPE(r=0.491,0.502,0.546,P<0.05).【Conclusion】The levels of FiB,D-D,sFlt-1 and vWF in the HSPN children were significantly increased,which may be associated with early renal injury of HSP.

关 键 词：肾炎 紫癜 纤维蛋白原 纤维蛋白纤维蛋白原降解物 蛋白酪氨酸激酶类 von WILLEBRAND因子 

分 类 号：R725.546[医药卫生—儿科]