外周血CD4^(+)T细胞计数对免疫性血小板减少症患者药物治疗效果评估作用分析  

Analysis of the effect of peripheral blood CD4^(+)T cell count on the evaluation of drug treatment effect in patients with immune thrombocytopenia

作　　者：汪琼 汪勇 吴玉玲 WANG Qiong;WANG Yong;WU Yuling(Department of Hematology and Rheumatology,Huangshan People’s Hospital,Anhui Province,Huangshan 245099,China)

机构地区：[1]安徽省黄山市人民医院血液风湿科,安徽黄山245099

出　　处：《中国医药导报》2022年第23期121-124,共4页China Medical Herald

摘　　要：目的分析外周血CD4^(+)T细胞计数对免疫性血小板减少症(ITP)患者药物治疗效果评估作用。方法选取2018年1月至2020年12月于安徽省黄山市人民医院(以下简称“我院”)就诊且入院后采取糖皮质激素药物治疗的80例ITP患者为研究组,以同期于我院体检的30名健康志愿者为对照组,比较研究组治疗前两组外周血CD4^(+)T细胞计数差异,比较研究组治疗前后外周血CD4^(+)T细胞计数变化。根据治疗效果将研究组分为有效组(62例)和无效组(18例),比较有效组和无效组的疾病相关指标,分析治疗效果的影响因素,以及外周血CD4^(+)T细胞计数对治疗效果的预测价值。结果研究组治疗前,研究组外周血CD4^(+)T细胞计数低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组外周血CD4^(+)T细胞计数高于治疗前,差异有统计学意义(P<0.05)。有效组巨核细胞计数、外周血CD4^(+)T细胞计数水平高于无效组,差异有统计学意义(P<0.05)。多因素分析结果显示,巨核细胞计数、外周血CD4^(+)T细胞计数是ITP患者药物治疗效果的影响因素(P<0.05)。外周血CD4^(+)T细胞计数对ITP患者药物治疗效果的受试者操作特征曲线下面积为0.765(P<0.05)。结论外周血CD4^(+)T细胞计数在ITP患者体内表达异常,是ITP患者药物治疗效果的影响因素,且对ITP患者药物治疗效果具有一定的预测价值。Objective To analyze the effect of peripheral blood CD4^(+)T cell count on the evaluation of drug treatment effect in patients with immune thrombocytopenia(ITP).Methods A total of 80 ITP patients admitted to Huangshan People’s Hospital,Anhui Province(hereinafter referred to as“our hospital”)from January 2018 to December 2020 who received glucocorticoid treatment after admission were selected as the study group,and 30 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group.Difference in peripheral blood CD4^(+)T cell count before the treatment of stndy group were compared between the two groups.The changes of peripheral blood CD4^(+)T cell count before and after treatment were compared in the study group.The study group was divided into the effective group(62 cases)and the ineffective group(18 cases)according to the treatment effect.The disease-related indicators of the effective group and the ineffective group were compared,and the factors influencing the treatment effect were analyzed,as well as the predictive value of peripheral blood CD4^(+)T cell count on the treatment effect.Results Before the treatment of study group,the peripheral blood CD4^(+)T cell count of the study group was lower than that of the control group,the difference was statistically significant(P<0.05).After treatment,the peripheral blood CD4^(+)T cell count of the study group was higher than that before treatment,the difference was statistically significant(P<0.05).The megakaryocytes count and peripheral blood CD4^(+)T cell count of effective group were higher than those of ineffective group,and the differences were statistically significant(P<0.05).Multivariate analysis showed that megakaryocyte count and peripheral blood CD4^(+)T cell count were the influencing factors of drug treatment effect in ITP patients(P<0.05).The area under the receiver operating characteristic curve of peripheral blood CD4^(+)T cell count on drug treatment effect of ITP patients was 0.7

关 键 词：CD4^(+)T细胞计数 外周血 免疫性血小板减少症 

分 类 号：R558.2[医药卫生—血液循环系统疾病]