中药熏蒸法联合龙胆泻肝汤治疗成年女性反复发作性尿路感染的效果  

Effect of traditional Chinese medicine fumigation method combined with Longdan Xiegan Decoction in the treatment of recurrent urinary tract infection in adult female

作　　者：葛树龙 陈蕾 杨晓蕾 GE Shulong;CHEN Lei;YANG Xiaolei(Department of Traditional Chinese Medicine,Shandong Provincial Third Hospital,Shandong Province,Jinan 250031,China)

机构地区：[1]山东省立第三医院中医科,山东济南250031

出　　处：《中国医药导报》2022年第23期137-141,共5页China Medical Herald

基　　金：山东省中医药科技发展计划项目(2019-0333)。

摘　　要：目的探究中药熏蒸法联合龙胆泻肝汤治疗成年女性反复发作性尿路感染的效果。方法选取山东省立第三医院2019年1月至2021年1月收治的108例成年女性反复发作性尿路感染患者,采取随机数字表法将其分为熏蒸组、汤剂组及联合组,每组各36例。全部患者采取一线药物治疗,在此基础上,熏蒸组给予中药熏蒸治疗,汤剂组给予龙胆泻肝汤治疗,联合组给予中药熏蒸联合龙胆泻肝汤治疗,连续治疗4周。比较三组的临床疗效、尿细菌转阴率、主要症状消失时间、中医证候积分、炎症因子水平,同时观察三组治疗期间不良反应情况。结果联合组的治疗总有效率及尿细菌转阴率均高于熏蒸组、汤剂组,差异有统计学意义(P<0.05)。联合组的尿频、尿急、小便涩痛、血尿及下股疼痛消失时间均短于熏蒸组、汤剂组,差异有统计学意义(P<0.05)。治疗后,三组的中医证候积分均低于治疗前,联合组的中医证候积分低于熏蒸组、汤剂组,差异有统计学意义(P<0.05)。治疗后,三组的超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-6、IL-8、肿瘤坏死因子-α(TNF-α)及降钙素原(PCT)水平均低于治疗前,且联合组的hs-CRP、IL-6、IL-8、TNF-α及PCT水平均低于熏蒸组、汤剂组,差异有统计学意义(P<0.05)。三组治疗期间均未见明显的不良反应,肝肾功能正常,无休克、无腹泻。结论中药熏蒸法联合龙胆泻肝汤治疗成年女性反复发作性尿路感染,可有效改善患者的临床症状及体征,提高尿细菌转阴率,缩短主要症状消失时间,调整炎症因子水平,且治疗期间无明显不良反应,保证了治疗期间的安全性。Objective To explore the effect of traditional Chinese medicine fumigation method combined with Longdan Xiegan Decoction in the treatment of recurrent urinary tract infection in adult female.Methods A total of 108 adult female patients with recurrent urinary tract infection admitted to Shandong Provincial Third Hospital from January 2019 to January 2021 were selected,and they were divided into fumigation group,decoction group and combined group according to the random number table method,with 36 cases in each group.All patients were treated with first-line drugs.On this basis,the fumigation group was treated with traditional Chinese medicine fumigation,the decoction group was treated with Longdan Xiegan Decoction,and the combined group was treated with traditional Chinese medicine fumigation and Longdan Xiegan Decoction for four weeks.The clinical efficacy,urinary bacterial negative conversion rate,disappearance time of main symptoms,traditional Chinese medicine syndrome score and inflammatory factor level of the three groups were compared,and the adverse reactions of the three groups during treatment were observed.Results The total effective rate and the negative conversion rate of urine bacteria in the combined group were higher than those in the fumigation group and the decoction group,and the differences were statistically significant(P<0.05).The disappearance times of frequency of urination,urgency of urination,astringent pain of urination,hematuria and lower thigh pain in the combined group were shorter than those in the fumigation group and the decoction group,and the differences were statistically significant(P<0.05).After treatment,the syndrome scores of the three groups were lower than those before treatment,and the traditional Chinese medicine syndrome scores of the combined group were lower than those of the fumigation group and the decoction group,the differences were statistically significant(P<0.05).After treatment,hypersensitivity C-reactive protein(hs-CRP),interleukin(IL)-6,IL-8,tumor necrosis fa

关 键 词：中药熏蒸法 龙胆泻肝汤 反复发作性尿路感染 疗效 尿细菌 炎症因子 不良反应 

分 类 号：R256.52[医药卫生—中医内科学]