利用点尿钠公式评估24小时尿钠排泄量的比较研究  

Comparative study on 24-hour urinary sodium excretion evaluated by point urinary sodium formula

作　　者：陈静[1] 初少莉[1] 陈歆[1] CHEN Jing;CHU Shaoli;CHEN Xin(Department of Hypertension,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 201821,China)

机构地区：[1]上海交通大学医学院附属瑞金医院高血压科,上海201821

出　　处：《世界临床药物》2022年第6期746-751,共6页World Clinical Drug

摘　　要：目的探讨不同点尿钠公式评估24 h尿钠排泄量的可行性分析。方法回顾性分析瑞金医院北部院区2016年5月至12月高血压科住院患者共226例,收集点尿、24 h尿进行尿钠测定,采用3种点尿钠公式Sun C法、Kawasaki法和Tanaka法估算24 h尿钠排泄量,通过配对秩和检验比较24 h尿钠估算值和测量值间的差异,利用Bland-Altman法对24 h尿钠的估算值和测量值进行一致性测评。结果3种点尿公式估算24 h尿钠[Sun C法137.4(111.0,161.8)mmol/d,Kawasaki法170.7(120.0,217.0)mmol/d,Tanaka法136.9(105.4,166.4)mmol/d]与实际测量值[142.7(103.8,183.5)mmol/d]比较,差异均存在统计学意义(P<0.05)。在男性患者中,Sun C法估算24 h尿钠结果与实际测量值差别最小,且差异无统计学意义(P>0.05);在女性患者中,Kawasaki法和Tanaka法估算24 h尿钠结果与实际测量值比较,差异无统计学意义(P>0.05),而Sun C法估算24 h尿钠结果与实际测量值比较,差异存在统计学意义(P<0.05)。结论入选高血压患者当中,3种公式估算的24 h尿钠结果可靠性均不高,按照性别分组后,Sun C法对于估算住院男性患者意义高于女性。Objective To explore the feasibility of different point urinary sodium formula to evaluate 24-hour urinary sodium excretion.Methods A total of 226 inpatients in the department of hypertension,northern area of Ruijin hospital from May to December 2016 were analyzed retrospectively.Point urine and 24-hour urinary sodium excretion was estimated by three point urine sodium formulas,Sun C method,Kawasaki method and Tanaka method.The differences between 24h urinary sodium estimated value and measured value were compared by paired rank sum test.The consistency of 24-hour urinary sodium estimated value and measured value was evaluated by Bland-Altman method.Results There were significant differences between the estimated 24-hour urinary sodium[Sun C method 137.4(111.0,161.8)mmol/d,Kawasaki method 170.7(120.0,217.0)mmol/d,Tanaka method 136.9(105.4,166.4)mmol/d]and the actual measured value[142.7(103.8,183.5)mmol/d](P<0.05).In male patients,the difference between 24-hour urinary sodium estimated by Sun C method and the actual measured value was the smallest,and there was no significant difference between them(P>0.05).In female patients,there was no significant difference between the estimated 24-hour urinary sodium by Kawasaki method and Tanaka method compared to the actual measured value(P>0.05),while there was significant difference between 24-hour urinary sodium estimated by Sun C method and the actual measured value(P<0.05).Conclusion The hospitalized patients with hypertension in our hospital,the reliability of 24-hour urinary sodium estimated by the three formulas is not high.After grouping according to gender,Sun C method has higher significance estimation of hospitalized male patients than female patients.

关 键 词：点尿钠 24小时尿钠 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]