祛腐清筋术联合红景天膏外用治疗糖尿病足溃疡临床研究  

Clinical Study on Method of Dispelling Ulcer and Clearing Tendons Combined with Rhodiola Root Ointment for External Application in the Treatment of Diabetes Foot Ulcer

作　　者：王晶 范力 李蔚 宁雪峰 曹烨民[2] 刘芳[3] WANG Jing;FAN Li;LI Wei;NING Xue-feng;CAO Ye-min;LIU Fang(Lanzhou Traditional Chinese Medicine Hospital,Lanzhou,Gansu,China,730050;Shanghai Traditional Chinese Medicine Integrated Hospital,Shanghai,China,200082;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou,Gansu,China,730050)

机构地区：[1]兰州市中医医院,甘肃兰州730050 [2]上海市中西医结合医院,上海200082 [3]甘肃省中医院,甘肃兰州730050

出　　处：《河南中医》2022年第10期1547-1551,共5页Henan Traditional Chinese Medicine

基　　金：甘肃省中医药管理局项目(GZK-2018-33);兰州市科技局人才创新项目(2016-RC-42)。

摘　　要：目的:观察祛腐清筋术联合红景天膏外用治疗糖尿病足溃疡的临床疗效。方法:选取2016年6月至2019年12月兰州市中医医院诊治的糖尿病足溃疡患者100例,随机分为常规清创组和中医治疗组,每组50例。常规清创组给予常规清创换药,中医治疗组给予奚氏祛腐清筋术联合红景天膏外敷治疗。观察两组患者治疗后病足创面愈合情况、患肢足背动脉血流动力学和炎症指标水平变化情况,比较两组患者的临床疗效和不良反应发生率。结果:常规清创组有效率为84.00%,中医治疗组有效率为96.00%,中医治疗组有效率高于常规清创组,差异有统计学意义(P<0.05);中医治疗组治疗后肿瘤坏死因子-α、白细胞介素-6水平低于常规清创组,内皮生长因子和碱性成纤维细胞生长因子水平高于常规清创组,差异有统计学意义(P<0.05);两组患者治疗前病足创面溃疡面积、肉芽组织面积比较,差异无统计学意义(P>0.05),中医治疗组治疗后病足创面溃疡面积小于常规清创组,肉芽组织面积大于常规清创组,溃疡面缩小率高于常规清创组,差异有统计学意义(P<0.05);两组患者治疗前患肢足背动脉血流动力学指标比较,差异无统计学意义(P>0.05),中医治疗组治疗后足背动脉血流速度、血管内径大于常规清创组,差异有统计学意义(P<0.05)。结论:祛腐清筋术联合红景天膏外用治疗糖尿病足溃疡可缩小病足创面面积,促进创面愈合,其原因与抑制炎症指标和患肢足背动脉血流动力学指标有关。Objective:To observe the clinical efficacy of method of dispelling ulcer and clearing tendons combined with Rhodiola Root Ointment for external application on diabetes foot ulcer.Methods:A total of 100 patients with diabetes foot ulcer diagnosed and treated in Lanzhou Traditional Chinese Medicine Hospital from June 2016 to December 2019 were randomly divided into the conventional debridement group and the TCM treatment group,with 50 patients in each group.The routine debridement group was given routine debridement and dressing change,while the TCM treatment group was given Master Xi's method of dispelling ulcer and clearing tendons combined with external application of Rhodiola Root Ointment.After treatment,the wound healing,hemody-namics and inflammatory indexes of the dorsal foot artery of the affected limbs were observed,and the clinical efficacy and adverse reactions of the two groups were compared.Results:The effective rate of the conventional debridement group was 84.00%,and that of the TCM treatment group was 96.00%.The effective rate of the TCM treatment group was higher than that of the conventional debridement group,and the difference was statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-αand interleukin,IL-6 were lower than those in the conventional debridement group,while the levels of vascular endothelial growth factors and basic fibroblast growth factor were higher than those in the conventional debridement group.All the differences were statistically significant(P<0.05).There were no significant differences in ulcer area and granulation tissue area between the two groups before treatment(P>0.05).After treatment,the ulcer area of the foot wound in the TCM treatment group was smaller than that in the conventional debridement group,while the granulation tissue area was larger than that in the conventional debridement group,and the reduction rate of the ulcer surface was higher than that in the conventional debridement group,and all the differ-ences were statistical

关 键 词：糖尿病足溃疡 祛腐清筋术 红景天膏 

分 类 号：R259[医药卫生—中西医结合]