肿瘤专科医院血培养病原菌分布及耐药性研究  

Distribution and drug resistance of bacteria in positive blood culture of a tumor hospital

作　　者：霍然 李俊毅 陈岩松[1] 陈丽妹[1] 辛娜[1] 艾新发 吴钰婷 陈燕[1] HUO Ran;LI Jun-yi;CHEN Yan-song;CHEN Li-mei;XIN Na;AI Xin-fa;WU Yu-ting;CHEN Yan(Fujian Medical University Cancer Hospital,Fujian Cancer Hospital,Fuzhou Fujian 350014;Fujian Medical University,School of Medical Technology and Engineering;Fujian Health College,China)

机构地区：[1]福建医科大学附属肿瘤医院福建省肿瘤医院,福建福州350014 [2]福建医科大学医学技术与工程学院 [3]福建卫生职业技术学院

出　　处：《中国消毒学杂志》2022年第8期610-612,615,共4页Chinese Journal of Disinfection

摘　　要：目的了解医院血培养病原菌分布及耐药情况。方法通过细菌分离培养和药敏试验方法,对医院血培养病原菌分布及其耐药性进行调查与分析。结果从9681套肿瘤患者血培养标本中分离出847株病原菌,革兰阴性菌占66.59%,其中大肠埃希菌占38.02%,肺炎克雷伯菌占13.11%;革兰阳性菌占29.63%,其中人型葡萄球菌及表皮葡萄球菌占7.91%,金黄色葡萄球菌占5.79%。大肠埃希菌对氨苄西林耐药率大于70.00%,葡萄球菌对青霉素高度耐药,耐甲氧西林金黄色葡萄球菌约占25.00%。结论肿瘤患者血流感染致病菌基本以革兰阴性菌为主,多数病原菌严重耐药。Objective To know the distribution and antibiotic resistance of pathogenic bacteria in blood culture in hospital.Methods Bacterial isolation and drug sensitivity test were used to survey and analyze the distribution and antibiotic resistance of pathogenic bacteria in blood culture in hospital.Results The 847 pathogenic bacteria were isolated from 9681 blood culture of tumor patients.Gram-negative bacteria accounted for 66.59%,of them Escherichia coli and Klebsiella pneumonia accounted for 38.02% and 13.11%respectively.Gram-positive bacteria accounted for 29.63%,of them Staphylococcus epidermidis and Staphylococcus aureus accounted for 7.91%and 5.79% respectively.The resistance rate of Escherichia coli to cefazolin and ampicillin was more than 70%.Staphylococcus was highly resistant to penicillin,and methicillin-resistant Staphylococcus aureus accounted for about 25%.Conclusion The pathogenic bacteria of blood stream infection in tumor patients are mainly gram-negative bacteria,and their antibiotic resistance is more serious.

关 键 词：肿瘤患者 血流感染 病原菌分布 耐药性 

分 类 号：R378[医药卫生—病原生物学] R183[医药卫生—基础医学]