几种A型肉毒毒素制剂的比较  

Comparisons of several formulations of botulinum toxin type A

作　　者：喻冬蕾 陈冠中 王杭[1] Yu Donglei;Chen Guanzhong;Wang Hang(Department of Plastic and Cosmetic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Distinct HealthCare,Shenzhen 518000,China)

机构地区：[1]四川大学华西口腔医院医疗美容科,成都610041 [2]卓正医疗,深圳518000

出　　处：《中华整形外科杂志》2022年第7期839-845,共7页Chinese Journal of Plastic Surgery

摘　　要：2020年,2种A型肉毒毒素(BoNT-A)正式获中国国家药品监督管理局批准上市,分别为AbobotulinumtoxinA(吉适)和LetibotulinumtoxinA(乐提葆)。为了比较不同BoNT-A制剂的差异,该文对国际上研究得较多的3种BoNT-A[AbobotulinumtoxinA、OnabotulinumtoxinA(保妥适)、IncobotulinumtoxinA]和国内的2种BoNT-A[LanbotulinumtoxinA(衡力)、LetibotulinumtoxinA],从制剂的扩散范围、换算比例、起效时间、维持时间、免疫原性及不良反应等方面进行了详细的总结,为临床应用提供参考。In 2020,two formulations of botulinum toxin type A(BoNT-A)named AbobotulinumtoxinA(Dysport■)and LetibotulinumtoxinA(Letybo■)have been officially approved by National Medical Products Administration to come on the market.To compare BoNT-As with different formulations,three BoNT-As[AbobotulinumtoxinA,OnabotulinumtoxinA(Botox■),IncobotulinumtoxinA(Xeomin■)]with relatively more clinical evidences internationally and two domestic BoNT-As[LanbotulinumtoxinA(Prosigne■),LetibotulinumtoxinA]were included.Diffusion scale,conversion ratio,onset,duration and immunogenicity of different BoNT-As were reviewed in detail to provide reference for clinical practice.

关 键 词：A型肉毒毒素 起效时间 维持时间 不良反应 

分 类 号：R95[医药卫生—药学]