Wnt/β-catenin信号通路相关基因与子宫内膜异位症患者生殖道解脲支原体感染的关系  

Relationship between Wnt/β-catenin signaling pathway-related genes and genital tract Ureaplasma urealyticum infection in patients with endometriosis

作　　者：李战娜 张秀丽 吴淑芬 李晓静 LI Zhan-na;ZHANG Xiu-li;WU Shu-fen;LI Xiao-jing(The Second Affiliated Hospital of Luohe Medical College,Luohe,Henan 462300,China)

机构地区：[1]漯河市医学高等专科学校第二附属医院妇产科,河南漯河462300

出　　处：《中华医院感染学杂志》2022年第2期252-255,共4页Chinese Journal of Nosocomiology

基　　金：河南省科研基金资助项目(2019HN121)。

摘　　要：目的 分析Wnt/β-catenin信号通路相关基因水平与子宫内膜异位症(EMS)患者生殖道解脲支原体(UU)感染的关系。方法 选择漯河市医学高等专科学校第二附属医院2019年1月-2020年1月收治的260例EMS患者,按是否存在UU感染分为UU感染组(n=69)、非感染组(n=191),比较两组患者临床资料和Wnt-7a、β-catenin、Frizzled7、基质金属蛋白酶-9(MMP-9)mRNA表达;Logistic逐步回归分析UU感染与Wnt/β-catenin信号通路相关基因的关系。结果 UU感染组患者年龄高于非感染组(P<0.05),两组子宫内膜异位症生育力指数(EFI)评分、输卵管最低功能(LF)评分、美国生育学会修订的EMT分期标准(r-AFS)分期比较差异有统计学意义(P<0.05);UU感染组Wnt-7a、β-catenin、Frizzled7、MMP-9 mRNA表达均高于非感染组(P<0.05);Logistic逐步回归分析显示Frizzled7 mRNA、Wnt-7a mRNA与EFI评分、LF评分均是EMS患者UU感染的独立影响因素(P<0.05)。结论 EMS合并UU感染患者Wnt/β-catenin信号通路相关基因水平较单纯EMS患者明显上调,其中Frizzled7 mRNA、Wnt-7a mRNA是EMS患者UU感染的独立影响因素,值得临床重视。OBJECTIVE To observe the relationship between Wnt/β-catenin signaling pathway-related genes and genital tract Ureaplasma urealyticum(Uu) infection in patients with endometriosis(EMS). METHODS A total of 260 EMS patients who were treated in The Second Affiliated Hospital of Luohe Medical College from Jan 2019 to Jan 2020 were enrolled in the study and divided into the Uu infection group with 69 cases and the non-infection group with 191 cases according to the status of Uu infection. The clinical data and expression levels of Wnt-7a mRNA, β-catenin mRNA, Frizzled7 mRNA, and matrix metalloproteinase-9(MMP-9) mRNA were compared between the two groups of patients, and logistic stepwise regression analysis was performed for the relationship between the Uu infection and the Wnt/β-catenin signaling pathway-related genes. RESULTS The patients of the Uu infection group were significantly older than those of the non-infection group(P<0.05). There were significant differences in the endometriosis fertility index(EFI) score, significantly lowest tubal function(LF) score and the EMT staging standard revised by the American Fertility Society(r-AFS) stage between the two groups(P<0.05). The expression levels of Wnt-7a mRNA, β-catenin mRNA, Frizzled7 mRNA and MMP-9 mRNA of the Uu infection group were significantly higher than those of the non-infection group(P<0.05). The logistic stepwise regression analysis showed that Frizzled7 mRNA, Wnt-7a mRNA, EFI score and LF score were the independent influencing factors for the Uu infection in the EMS patients(P<0.05). CONCLUSION The expression levels of Wnt/β-catenin signaling pathway-related genes are up-regulated more significantly in the EMS patients complicated with Uu infection than in the patients with EMS alone. Frizzled7 mRNA and Wnt-7a mRNA are the independent influencing factors for Uu infection in the EMS patients, which should be attached great importance to.

关 键 词：子宫内膜异位症 生殖道 解脲支原体感染 WNT/Β-CATENIN信号通路 

分 类 号：R711.71[医药卫生—妇产科学]