基于巨噬细胞的动脉粥样硬化易损斑块靶向成像的研究进展  

Advances in molecular imaging by targeting macrophages of atherosclerosis vulnerable plaques

作　　者：石彩云 王灵杰 张华[2] Shi Caiyun;Wang Lingjie;Zhang Hua(Department of Medical Imaging,Shanxi Medical University,Taiyuan 030000,China;Department of Medical Imaging,First Hospital of Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学医学影像学院,太原030000 [2]山西医科大学第一医院影像科,太原030000

出　　处：《中华核医学与分子影像杂志》2022年第8期499-503,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：山西省重点研发计划项目(201703D321015-3,201803D31109)。

摘　　要：易损斑块破裂是导致急性心脑血管疾病的主要原因之一。巨噬细胞是易损斑块中主要的炎性细胞,与易损斑块的发生、发展及破裂密切相关。对易损斑块的早期诊断及干预能降低急性心脑血管疾病死亡率,而分子影像的发展为早期成像提供了可能。文章对易损斑块中与巨噬细胞相关的分子标志物及目前用于巨噬细胞靶向成像的分子探针进行了综述。Vulnerable plaque rupture is the leading cause of acute cardiovascular diseases.Macrophages are main inflammatory cells closely related to the rupture of vulnerable plaques.Early diagnosis of vulnerable plaque can reduce the mortality of acute cardiovascular diseases.With the development of molecular imaging,the possibility for early identification of vulnerable plaques may come true.This review summarizes the changes of molecular markers of macrophages in vulnerable plaques and the molecular probes that can target macrophages.

关 键 词：斑块 动脉粥样硬化 分子显像 巨噬细胞 发展趋势 

分 类 号：R54[医药卫生—心血管疾病] R743[医药卫生—内科学]