变应性鼻炎患者血清ECP、ICAM-1、Eotaxin水平与其疾病状态及症状的关系  

Relationship between serum ECP,ICAM-1 and eotaxin levels in patients with allergic rhinitis and their disease state and symptoms

作　　者：李红娟[1] 张珂[1] 蔡文杰[2] LI Hongjuan;ZHANG Ke;CAI Wenjie(Department of Otolaryngology,Anyang Sixth People's Hospital,Anyang,Henan,China,455000;Department of Clinical Laboratory,Anyang Regional Hospital,Anyang,Henan,China,455000)

机构地区：[1]安阳市第六人民医院耳鼻喉科,河南安阳455000 [2]安阳地区医院临床实验室,河南安阳455000

出　　处：《分子诊断与治疗杂志》2022年第8期1371-1374,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(201912318)。

摘　　要：目的分析变应性鼻炎(AR)患者血清嗜酸细胞阳离子蛋白(ECP)、细胞间黏附分子-1(ICAM-1)及嗜酸性粒细胞趋化因子(Eotaxin)水平与其疾病状态、症状的关系。方法分析本院2020年1月至2022年4月门诊收治的156例AR患者的临床资料。另同期选取在本院进行健康体检的83名健康者作为对照组。比较两组及不同疾病状态、症状评分AR患者ECP、ICAM-1及Eotaxin水平;并采用Pearson分析ECP、ICAM-1及Eotaxin水平与AR临床症状的相关性。结果AR组ECP、ICAM-1及Eotaxin水平均明显高于对照组,差异具有统计学意义(t=42.075、11.083、42.243,P<0.05)。持续性AR组患者ECP、ICAM-1及Eotaxin水平均明显高于间歇性AR组,差异具有统计学意义(t=41.409、8.596、10.294,P<0.05)。不同症状评分AR患者ECP、ICAM-1及Eotaxin水平比较:0~2分组<3~4分组<≥5分组,差异具有统计学意义(F=794.36、42.50、124.72,P<0.05)。相关性结果示,ECP、ICAM-1及Eotaxin水平与间歇性AR患者SFAR评分呈负相关;与持续性AR患者SFAR评分呈正相关(P<0.05)。结论血清ECP、ICAM-1及Eotaxin水平在AR患者中呈高表达,且与其疾病状态、症状存在一定相关性。Objective To analyze the relationship between serum eosinophil cationic protein(ECP),intercellular adhesion molecule-1(ICAM-1)and eosinophil chemokine(Eotaxin)levels and disease states and symptoms in allergic rhinitis(AR)patients.Methods The clinical data of 156 AR patients admitted to the outpatient clinic of our hospital from January 2020 to April 2022 were analyzed,83 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.The levels of ECP,ICAM-1 and eotaxin and AR patients with different disease states and symptom scores were compared between the two groups.Pearson was used to analyze the correlation between the levels of ECP,ICAM-1 and eotaxin and the clinical symptoms of AR.Results The levels of ECP,ICAM-1 and eotaxin in the AR group were significantly higher than those in the control group,and the difference was statistically significant(t=42.075,11.083,42.243,P<0.05).The levels of ECP,ICAM-1 and eotaxin in the persistent AR group were significantly higher than those in the intermittent AR group,and the difference was statistically significant(t=41.409,8.596,10.294,P<0.05).Comparison of ECP,ICAM-1 and eotaxin levels in AR patients with different symptom scores:0~2 group<3~4 group<≥5 group,the difference was statistically significant(F=794.36,42.50,124.72,P<0.05).The correlation results showed that the levels of ECP,ICAM-1 and eotaxin were negatively correlated with the SFAR score of patients with intermittent AR and were positively correlated with the SFAR score of patients with persistent AR(P<0.05).Conclusion Serum ECP,ICAM-1 and eotaxin levels are highly expressed in AR patients,and there is a certain correlation with their disease state and symptoms.

关 键 词：变应性鼻炎 嗜酸细胞阳离子蛋白 细胞间黏附分子-1 趋化因子Eotaxin 疾病状态 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]