Apo-B、Hcy、Apo-A预测慢性心力衰竭疗效价值及生存状况分析  

Analysis of Apo-B,Hcy,Apo-A in predicting the efficacy and survival of chronic heart failure

作　　者：王丽兰 刘慧[1] 王逸君 秦小敏 WANG Lilan;LIU Hui;WANG Yijun;QIN Xiaomin(Department of Cardiology,South Wannan Rehabilitation Hospital,The Fifth People's Hospital of Wuhu,Wuhu,Anhui,China,241000)

机构地区：[1]安徽省皖南康复医院·芜湖市第五人民医院心内科,安徽芜湖241000

出　　处：《分子诊断与治疗杂志》2022年第8期1420-1423,共4页Journal of Molecular Diagnostics and Therapy

基　　金：芜湖市卫生健康委科研项目(WHWJ2021y085)。

摘　　要：目的探讨载脂蛋白B(Apo-B)、同型半胱氨酸(Hcy)、载脂蛋白A(Apo-A)预测慢性心力衰竭(CHF)疗效价值及生存状况。方法选取2018年2月至2021年11月安徽芜湖市第五人民院心内科144例CHF患者作为研究组,均接受抗心力衰竭治疗,另纳入98名健康体检者作为对照组。统计研究组治疗前后有效(70例显效,45例有效)、无效患者及对照组血Apo-B、Hcy、Apo-A水平,Pearson相关系数模型分析血清各指标与抗心力衰竭效果,采用受试者工作特征(ROC)曲线、卡普兰-迈耶曲线(K-M)分析血清各指标与抗心力衰竭效果、生存率关系。结果治疗前研究组有效、无效患者血清Apo-B、Hcy、Apo-A水平高于对照组,差异有统计学意义(P<0.05);治疗2周后、4周后研究组有效患者血清Apo-B、Hcy、Apo-A水平低于无效患者,差值大于无效患者,差异有统计学意义(P<0.05);CHF患者血清Apo-B、Hcy、Apo-A水平与抗心力衰竭效果呈负相关(P<0.05);三者差值联合预测抗心衰治疗无效AUC为0.911(95%CI:0.852~0.952),优于单独预测;血清Apo-B、Hcy、Apo-A高水平患者生存率均低于Apo-B、Hcy、Apo-A低水平患者(P<0.05)。结论CHF患者Apo-B、Hcy、Apo-A高表达与抗心力衰竭效果相关,联合检测有利于预测抗心力衰竭效果,指导后续治疗。Objective To investigate the value of apolipoprotein B(Apo-B),homocysteine(Hcy),and apolipoprotein A(Apo-A)in predicting the efficacy and survival of chronic heart failure(CHF).Methods 144 patients with CHF from February 2018 to November 2021 in the Department of Cardiology,the Fifth People’s Hospital of Wuhu City,Anhui Province,were selected as the study group,all of whom received anti-heart failure treatment,and another 98 healthy physical examiners were included as the control group.The serum Apo-B,Hcy,Apo-A levels of effective(70 significant,45 effective)and ineffective patients and the control group before and after treatment were measured in the study group,and the Pearson correlation coefficient model was used to analyze the serum indicators and anti-heart failure effect,and the subject operating characteristic(ROC)curve and Kaplan-Meyer curve(K-M)were used to analyze the serum indicators and anti-heart failure effect and survival rate.The relationship between serum indices and anti-heart failure effect and survival rate was analyzed using ROC curve and Kaplan-Meyer curve(K-M).Results Serum ApoB,Hcy,and Apo-A levels were higher in effective and ineffective patients in the study group than those in the control group before treatment,and the difference was statistically significant(P<0.05).Serum Apo-B,Hcy,and Apo-A levels were lower in effective patients than in ineffective patients in the study group after 2 weeks and 4 weeks of treatment,and the difference was greater than in ineffective patients,and the difference was statistically significant(P<0.05).Serum Apo-B,Hcy,and Apo-A levels in CHF patients were negatively correlated with the effect of anti-heart failure(P<0.05).The AUC of the three differences combined to predict the ineffectiveness of anti-heart failure treatment was 0.911(95%CI:0.852-0.952),which was better than the independent prediction.The survival rate of patients with high levels of serum Apo-B,Hcy and Apo-A was lower than that of patients with low levels of Apo-B,Hcy and Apo-A(P<0.05).

关 键 词：慢性心力衰竭 APO-B HCY Apo-A 抗心力衰竭 治疗效果 生存状况 

分 类 号：R541.6[医药卫生—心血管疾病]