RF、Anti-CCP抗体及ESR对RA疾病活动度和治疗后复发的评估价值  

Evaluation of RF,anti-CCP antibody and ESR in RA disease activity and recurrence after treatment

作　　者：肖华 梁永钢 张书娟 谢林森 封利欣 XIAO Hua;LIANG Yonggang;ZHANG Shujuan;XIE Linsen;FENG Lixin(Department of Clinical Laboratory,Zhengzhou Central Hospital,Zhengzhou University,Zhengzhou,Henan,China,450007;Department of Rheumatology,Zhengzhou Central Hospital,Zhengzhou University,Zhengzhou,Henan,China,450007)

机构地区：[1]郑州大学附属郑州中心医院检验科,河南郑州450007 [2]郑州大学附属郑州中心医院风湿免疫科,河南郑州450007

出　　处：《分子诊断与治疗杂志》2022年第8期1424-1427,1432,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(LHGJ20210774)。

摘　　要：目的探究类风湿因子(RF)、抗环瓜氨酸肽抗体(Anti-CCP)及红细胞沉降率(ESR)水平对类风湿性关节炎(RA)疾病活动度和治疗后复发的评估价值。方法以2019年1月到2020年12月郑州大学附属郑州中心医院收治的106例类风湿性关节炎患者为观察组,并根据RA疾病活动指数(DAS28)分为高活动度、中活动度、低活动度三个亚组,根据复发情况分为复发组、未复发组两个亚组。以同期50名健康体检者为对照组。检测两组及观察组不同疾病活动度、不同复发情况患者RF、AntiCCP抗体及ESR水平,使用Spearman相关分析RF、Anti-CCP抗体及ESR水平对类风湿性关节炎疾病活动度和治疗后复发的相关性,并通过ROC曲线分析RF、Anti-CCP抗体、ESR水平及联合检测对治疗后复发的预测价值。结果观察组患者的RF、Anti-CCP抗体及ESR水平为明显高于对照组,差异有统计学意义(P<0.05)。根据不同疾病活动度将观察组分为高活动度24例、中活动度54例、低活动度28例。RF、Anti-CCP抗体及ESR水平:高活动度组>中活动度组>轻活动度组,差异有统计学意义(P<0.05)。106例患者中,复发的16例,未复发的90例。未复发组患者的RRF、Anti-CCP抗体及ESR水平明显低于复发组,差异有统计学意义(P均<0.05)。Spearman相关分析显示观察组患者的RF、Anti-CCP抗体及ESR水平与疾病活动度、复发具有明显的相关性(P均<0.05)。以患者的RF、Anti-CCP抗体及ESR含量变化建立ROC分析模型,RF、Anti-CCP抗体、ESR及联合预测治疗后复发曲线下面积为0.635、0.662、0.698、0.825,患者RF、Anti-CCP抗体及ESR对治疗后复发有一定的预测价值。结论RF、Anti-CCP抗体及ESR水平与类风湿性关节炎的疾病活动度均存在一定的相关性,对患者疾病活动度和预后复发有一定的评估价值。Objective To investigate the evaluation value of rheumatoid factor(RF),anti-cyclic citrullinate peptide antibody(anti-CCP)and erythrocyte sedimentation rate(ESR)levels on disease activity and recurrence of rheumatoid arthritis(RA)after treatment.Methods A total of 106 patients with rheumatoid arthritis admitted to Zhengzhou Central Hospital affiliated to Zhengzhou University from January 2019 to December 2020 were selected as the observation group,and were divided into three subgroups according to RA activity index(DAS28),high activity,moderate activity and low activity,and two subgroups according to recurrence and non-recurrence.Fifty healthy subjects were selected as the control group.The levels of RF,anti-CCP antibody and ESR in patients with different disease activity and relapse were detected in the two groups and observation group.Spearman correlation analysis was used to analyze the correlation between RF,anti-CCP antibody and ESR levels on the activity of rheumatoid arthritis disease and relapse after treatment.ROC curve was used to analyze the prediction value of RF,anti-CCP antibody and ESR levels and combined detection for recurrence after treatment.Results The levels of RF,anti-CCP antibody and ESR in observation group were significantly higher than those in control group,the differences were statistically significant(P<0.05).The observation group was divided into 24 cases with high activity,54 cases with moderate activity and 28 cases with low activity according to different disease activity.The levels of RF,anti-CCP antibody and ESR in high activity group>medium activity group>light activity group were statistically significant(P<0.05).Of the 106 patients,16 relapsed and 90 did not.The levels of RRF,anti-CCP antibody and ESR in the non-recurrence group were significantly lower than those in the recurrence group,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that RF,anti-CCP antibody and ESR levels were significantly correlated with disease activity an

关 键 词：RF Anti-CCP抗体 ESR 类风湿性关节炎 

分 类 号：R593.22[医药卫生—内科学]